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MUC7 VNTR polymorphism and association with bronchial asthma in Egyptian children
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MUC7 VNTR polymorphism and association with bronchial asthma in Egyptian children
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Journal Article
MUC7 VNTR polymorphism and association with bronchial asthma in Egyptian children
2022
Overview
Overproduction of mucins in the airways donates largely to airway blockage in asthma patients. Glycoprotein MUC7 plays a role in the clearance of bacteria and has anti-candidacidal criteria. Our goal was to investigate the association between the
MUC7
variable number of tandem repeats (VNTR) polymorphism and bronchial asthma among Egyptian children. The
MUC7
VNTR polymorphism was investigated among 100 children with bronchial asthma and 100 healthy controls using polymerase chain reaction (PCR) method. Serum levels of immunoglobulin E (IgE), tumor necrosis factor-alpha (TNF-α), and transforming growth factor-beta1 (TGF-β1) were assessed by enzyme-linked immunosorbent assay (ELISA) technique. The frequencies of 6*5 genotype, 5*5 genotype, (6*5 + 5*5) genotypes, and
MUC7
*5 allele of the
MUC7
VNTR variant were significantly lower among asthmatic patients than controls (
p
< 0.015, OR = 0.39, 95% CI = 0.19–0.81;
p
= 0.03, OR = 0.18, 95% CI = 0.04–0.86;
p
< 0.001, OR = 0.29, 95% CI = 0.15–0.58;
p
< 0.001, OR = 0.3, 95% CI = 0.17–0.55, respectively). The (6*5 + 5*5) genotypes of the
MUC7
VNTR variant were not associated with the clinical manifestations and serum levels of IgE, TNF-α, and TGF-β1 among asthmatic patients (
p
˃ 0.05). In conclusion, the (6*5 + 5*5) genotypes of the
MUC7
VNTR variant may have a protective role for bronchial asthma in Egyptian children.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/45
/ Asthma
/ Child
/ Children
/ Egypt
/ Enzyme-linked immunosorbent assay
/ Genetic Predisposition to Disease
/ Genotype
/ Humanities and Social Sciences
/ Humans
/ Mucin
/ Mucins
/ Patients
/ Salivary Proteins and Peptides - genetics
/ Science
/ Transforming Growth Factor beta1 - genetics
/ Transforming growth factor-b
/ Transforming growth factor-b1
