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Yucasin DF, a potent and persistent inhibitor of auxin biosynthesis in plants
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Yucasin DF, a potent and persistent inhibitor of auxin biosynthesis in plants
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Journal Article
Yucasin DF, a potent and persistent inhibitor of auxin biosynthesis in plants
2017
Overview
The plant hormone auxin plays a crucial role in plant growth and development. Indole-3-acetic acid (IAA), a natural auxin, is mainly biosynthesized by two sequential enzyme reactions catalyzed by TAA1 and YUCCA (YUC). TAA1 is involved in the conversion of tryptophan to IPA, and YUC catalyzes the conversion of IPA to IAA. We previously demonstrated that yucasin inhibits AtYUC1 enzyme activity and suppress high-auxin phenotype of YUC overexpression plants, although yucasin displayed weak effects on the auxin-related phenotype of wild-type plants. To develop more potent YUC inhibitors, various derivatives of yucasin were synthesized, and their structure–activity relationships were investigated. Yucasin difluorinated analog (YDF) (5-[2,6-difluorophenyl]-2,4-dihydro-[1,2,4]-triazole-3-thione) was identified to be a more potent YUC inhibitor than the original yucasin. YDF caused an auxin-deficient phenotype in Arabidopsis wild-type plants that was restored with auxin application. YDF was found to be highly stable regarding metabolic conversion
in vivo
, accounting for the potent activity of the inhibition of IAA biosynthesis in planta. Photoaffinity labeling experiments demonstrated that yucasin-type inhibitors bind to the active site of AtYUC1. YDF is a promising auxin biosynthesis inhibitor and is a useful chemical tool for plant biology and agrochemical studies.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Arabidopsis - growth & development
/ Arabidopsis Proteins - antagonists & inhibitors
/ Enzymes
/ Gene Expression Regulation, Plant
/ Humanities and Social Sciences
/ Indoleacetic Acids - metabolism
/ Mixed Function Oxygenases - antagonists & inhibitors
/ Plant Growth Regulators - metabolism
/ Science
