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Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection
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Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection
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Journal Article
Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection
2020
Overview
Parental exposure to pathogens can prime offspring immunity in diverse organisms. The mechanisms by which this heritable priming occurs are largely unknown. Here we report that the soil bacteria
Pseudomonas vranovensis
is a natural pathogen of the nematode
Caenorhabditis elegans
and that parental exposure of animals to
P. vranovensis
promotes offspring resistance to infection. Furthermore, we demonstrate a multigenerational enhancement of progeny survival when three consecutive generations of animals are exposed to
P. vranovensis
. By investigating the mechanisms by which animals heritably adapt to
P. vranovensis
infection, we found that parental infection by
P. vranovensis
results in increased expression of the cysteine synthases
cysl-1
and
cysl-2
and the regulator of hypoxia inducible factor
rhy-1
in progeny, and that these three genes are required for adaptation to
P. vranovensis
. These observations establish a CYSL-1, CYSL-2, and RHY-1 dependent mechanism by which animals heritably adapt to infection.
Caenorhabditis elegans
exhibits multigenerational adaptation to bacterial infection but the mechanisms remain unclear. Here, the authors show that
C. elegans
parental exposure to
Pseudomonas vranovensis
promotes offspring resistance to infection, a process mediated by the cysteine synthases CYSL-1 and CYSL-2.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/35
/ 38/91
/ 64/11
/ 96/63
/ Adaptation, Physiological - genetics
/ Animals
/ Bacteria
/ Caenorhabditis elegans - embryology
/ Caenorhabditis elegans - enzymology
/ Caenorhabditis elegans - genetics
/ Caenorhabditis elegans - microbiology
/ Caenorhabditis elegans Proteins - genetics
/ Caenorhabditis elegans Proteins - metabolism
/ Cysteine
/ Cysteine Synthase - genetics
/ Cysteine Synthase - metabolism
/ Embryo, Nonmammalian - metabolism
/ Exposure
/ Gene Expression Regulation, Developmental
/ Humanities and Social Sciences
/ Hypoxia
/ Inheritance Patterns - genetics
/ Priming
/ Progeny
/ Science
/ Worms
