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Local Delivery of Paclitaxel to Inhibit Restenosis during Angioplasty of the Leg
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Local Delivery of Paclitaxel to Inhibit Restenosis during Angioplasty of the Leg
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Journal Article
Local Delivery of Paclitaxel to Inhibit Restenosis during Angioplasty of the Leg
2008
Overview
In a randomized trial, 154 patients with femoropopliteal-artery disease who were undergoing angioplasty were assigned to treatment with a paclitaxel-coated angioplasty balloon, an uncoated balloon with paclitaxel dissolved in the contrast medium, or an uncoated balloon without paclitaxel (control treatment). Late lumen loss, restenosis at 6 months, and target-lesion revascularization at 6, 12, and 24 months were significantly reduced with the paclitaxel-coated balloon but not with paclitaxel-containing contrast medium.
In patients with femoropopliteal-artery disease who were undergoing angioplasty, late lumen loss, restenosis at 6 months, and target-lesion revascularization at 6, 12, and 24 months were significantly reduced with a paclitaxel-coated balloon but not with paclitaxel-containing contrast medium.
Percutaneous transluminal angioplasty for revascularization of the superficial femoral artery has an initial technical success rate of more than 95%.
1
However, restenosis occurs in 40 to 60% of the treated segments after 6 to 12 months
2
–
4
; these rates are much higher than restenosis rates in other vascular beds, such as the coronary and renal arteries.
5
Stenting is more effective than balloon angioplasty for preventing restenosis in the coronary circulation, but a benefit of stenting in the vessels of the lower extremities remains to be confirmed.
6
–
9
Several other attempts to increase long-term patency in peripheral vascular disease have . . .
Publisher
Massachusetts Medical Society
Subject
/ Aged
/ Angioplasty, Balloon - adverse effects
/ Arterial Occlusive Diseases - drug therapy
/ Arterial Occlusive Diseases - pathology
/ Arterial Occlusive Diseases - therapy
/ Female
/ Femoral Artery - diagnostic imaging
/ Humans
/ Male
/ Paclitaxel - administration & dosage
/ Popliteal Artery - diagnostic imaging
/ Popliteal Artery - pathology
/ Stents
