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Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria
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Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria
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Journal Article
Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria
2018
Overview
Noble metal-based nanomaterials have shown promise as potential enzyme mimetics, but the facet effect and underlying molecular mechanisms are largely unknown. Herein, with a combined experimental and theoretical approach, we unveil that palladium (Pd) nanocrystals exhibit facet-dependent oxidase and peroxidase-like activities that endow them with excellent antibacterial properties via generation of reactive oxygen species. The antibacterial efficiency of Pd nanocrystals against Gram-positive bacteria is consistent with the extent of their enzyme-like activity, that is {100}-faceted Pd cubes with higher activities kill bacteria more effectively than {111}-faceted Pd octahedrons. Surprisingly, a reverse trend of antibacterial activity is observed against Gram-negative bacteria, with Pd octahedrons displaying stronger penetration into bacterial membranes than Pd nanocubes, thereby exerting higher antibacterial activity than the latter. Our findings provide a deeper understanding of facet-dependent enzyme-like activities and might advance the development of noble metal-based nanomaterials with both enhanced and targeted antibacterial activities.
Noble metal nanoparticles are potential antibacterial agents, perhaps owing to their enzyme-like activities. Here, the authors find that the exposed facets of palladium nanocrystals demonstrate their specific antibacterial behavior against both Gram-positive and Gram-negative bacteria.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/106
/ 13/51
/ 14/28
/ 14/63
/ 147/135
/ 147/138
/ 147/143
/ 147/3
/ Anti-Bacterial Agents - chemistry
/ Anti-Bacterial Agents - metabolism
/ Anti-Bacterial Agents - pharmacology
/ Bacteria
/ Crystals
/ Cubes
/ Enzymes
/ Gram-Negative Bacteria - drug effects
/ Gram-Negative Bacteria - growth & development
/ Gram-Positive Bacteria - drug effects
/ Gram-Positive Bacteria - growth & development
/ Humanities and Social Sciences
/ Microscopy, Electron, Transmission
/ Nanoparticles - ultrastructure
/ Oxidoreductases - metabolism
/ Reactive Oxygen Species - metabolism
/ Science
