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The ULK3 kinase is a determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
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The ULK3 kinase is a determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
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Journal Article
The ULK3 kinase is a determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
2023
Overview
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites, including skin and Head/Neck. ULK3 loss by gene silencing or deletion reduces proliferation and clonogenicity of human keratinocytes and SCC-derived cells and affects transcription impinging on stem cell-related and metabolism programs. Mechanistically, ULK3 directly binds and regulates the activity of two histone arginine methyltransferases, PRMT1 and PRMT5 (PRMT1/5), with ULK3 loss compromising PRMT1/5 chromatin association to specific genes and overall methylation of histone H4, a shared target of these enzymes. These findings are of translational significance, as downmodulating ULK3 by RNA interference or locked antisense nucleic acids (LNAs) blunts the proliferation and tumorigenic potential of SCC cells and promotes differentiation in two orthotopic models of skin cancer.
The identification of kinases that control epigenetic mechanisms in squamous cell carcinomas (SCCs) can be of therapeutic relevance. Here the authors show that loss of nuclear kinase ULK3 impairs the recruitment of two histone arginine methyltransferases, PRMT1 and PRMT5 to the promoter regions of genes of functions, hence, suppressing the tumorigenic potential of SCC cells.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/89
/ 45
/ 45/15
/ 45/41
/ 49/39
/ 49/61
/ 96
/ Arginine
/ Cancer
/ Cell Differentiation - genetics
/ Genes
/ Histones
/ Humanities and Social Sciences
/ Humans
/ Kinases
/ Protein Serine-Threonine Kinases - metabolism
/ Protein-Arginine N-Methyltransferases - metabolism
/ Repressor Proteins - metabolism
/ Science
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