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Prognostic value of PD-L1 and Siglec-15 expression in patients with nasopharyngeal carcinoma
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Prognostic value of PD-L1 and Siglec-15 expression in patients with nasopharyngeal carcinoma
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Prognostic value of PD-L1 and Siglec-15 expression in patients with nasopharyngeal carcinoma
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Journal Article
Prognostic value of PD-L1 and Siglec-15 expression in patients with nasopharyngeal carcinoma
2022
Overview
Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) might be involved in the activation of important pathways related to tumor immune escape, along with programmed death-ligand 1 (PD-L1). Here, we aimed to investigate the correlation between the expression of Siglec-15 and PD-L1 in nasopharyngeal carcinoma (NPC) patients. We determined the expression of PD-L1 via immunohistochemical staining and that of Siglec-15 via immunofluorescence staining in 182 NPC tissue samples. A significant correlation was identified between the PD-L1 and Siglec-15 expression (P = 0.000). Moreover, Kaplan–Meier survival curves showed that PD-L1 expression was associated with improved overall survival (OS) (P = 0.025) and Siglec-15 expression was associated with improved distant failure-free survival (D-FFS) (P = 0.048). Moreover, multivariate Cox analysis showed that PD-L1 and Siglec-15 were independent predictors of OS (P = 0.020) and D-FFS (P = 0.047), respectively. The results of the log-rank test and Cox regression analyses showed that patients exhibiting no PD-L1/Siglec-15 expression had significant advantages regarding OS, compared to other groups (P = 0.037). PD-L1 and Siglec-15 may represent novel biomarkers for predicting the prognosis of NPC patients. Siglec-15 may be considered as a potential target for the development of therapeutics for NPC treatment in the future.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/67
/ 692/4028
/ 692/699
/ B7-H1 Antigen - biosynthesis
/ Biomarkers, Tumor - biosynthesis
/ Biomarkers, Tumor - genetics
/ Humanities and Social Sciences
/ Humans
/ Immunoglobulins - biosynthesis
/ Membrane Proteins - biosynthesis
/ Nasopharyngeal Carcinoma - genetics
/ Nasopharyngeal Carcinoma - metabolism
/ Nasopharyngeal Carcinoma - pathology
/ Nasopharyngeal Neoplasms - genetics
/ Nasopharyngeal Neoplasms - metabolism
/ Nasopharyngeal Neoplasms - pathology
/ Patients
/ Science
/ Survival
/ Tumors
