Asset Details
Do you wish to reserve the book?
Alteration of the gut microbiota in Chinese population with chronic kidney disease
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Alteration of the gut microbiota in Chinese population with chronic kidney disease
Do you wish to request the book?
Alteration of the gut microbiota in Chinese population with chronic kidney disease
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Alteration of the gut microbiota in Chinese population with chronic kidney disease
2017
Overview
We evaluated differences in the compositions of faecal microbiota between 52 end stage renal disease (ESRD) patients and 60 healthy controls in southern China using quantitative real-time polymerase chain reaction (qPCR) and high-throughput sequencing (16S ribosomal RNA V4-6 region) methods. The absolute quantification of total bacteria was significantly reduced in ESRD patients (p < 0.01). In three enterotypes,
Prevotella
was enriched in the healthy group whereas
Bacteroides
were prevalent in the ESRD group (LDA score > 4.5). 11 bacterial taxa were significantly overrepresented in samples from ESRD and 22 bacterial taxa were overrepresented in samples from healthy controls. The butyrate producing bacteria,
Roseburia
,
Faecalibacterium
,
Clostridium
,
Coprococcus
and
Prevotella
were reduced in the ESRD group (LDA values > 2.0). Canonical correspondence analysis (CCA) indicated that Cystatin C (CysC), creatinine and eGFR appeared to be the most important environmental parameters to influence the overall microbial communities. In qPCR analysis, The butyrate producing species
Roseburia spp
.,
Faecalibacterium prausnitzii
,
Prevotella
and
Universal bacteria
, were negatively related to CRP and CysC. Total bacteria in faeces were reduced in patients with ESRD compared to that in healthy individuals. The enterotypes change from
Prevotella
to
Bacteroides
in ESRD patients. The gut microbiota was associated with the inflammatory state and renal function of chronic kidney disease.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/23
/ Adult
/ Aged
/ Bacteria
/ Computational Biology - methods
/ Epidermal growth factor receptors
/ Female
/ Humanities and Social Sciences
/ Humans
/ Kidney Failure, Chronic - epidemiology
/ Kidneys
/ Male
/ Medicare
/ Renal Insufficiency, Chronic - diagnosis
/ Renal Insufficiency, Chronic - epidemiology
/ Renal Insufficiency, Chronic - metabolism
/ rRNA 16S
/ Science
/ Taxa
