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A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding
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Journal Article
A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding
2020
Overview
Marked deficits in glucose availability, or glucoprivation, elicit organism-wide counter-regulatory responses whose purpose is to restore glucose homeostasis. However, while catecholamine neurons of the ventrolateral medulla (VLM
CA
) are thought to orchestrate these responses, the circuit and cellular mechanisms underlying specific counter-regulatory responses are largely unknown. Here, we combined anatomical, imaging, optogenetic and behavioral approaches to interrogate the circuit mechanisms by which VLM
CA
neurons orchestrate glucoprivation-induced food seeking behavior. Using these approaches, we found that VLM
CA
neurons form functional connections with nucleus accumbens (NAc)-projecting neurons of the posterior portion of the paraventricular nucleus of the thalamus (pPVT). Importantly, optogenetic manipulations revealed that while activation of VLM
CA
projections to the pPVT was sufficient to elicit robust feeding behavior in well fed mice, inhibition of VLM
CA
–pPVT communication significantly impaired glucoprivation-induced feeding while leaving other major counterregulatory responses intact. Collectively our findings identify the VLM
CA
–pPVT–NAc pathway as a previously-neglected node selectively controlling glucoprivation-induced food seeking. Moreover, by identifying the ventrolateral medulla as a direct source of metabolic information to the midline thalamus, our results support a growing body of literature on the role of the PVT in homeostatic regulation.
Catecholaminergic neurons of the ventrolateral medulla are known to drive diverse glucose counterregulatory responses to hypoglycemia. Here, the authors show that projections from these neurons onto nucleus accumbens-targeting neurons of the midline thalamus selectively mediate hypoglycemic feeding.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/51
/ 14/10
/ 14/19
/ 14/35
/ 42/44
/ 64/110
/ 9/74
/ Animals
/ Circuits
/ Feeding Behavior - physiology
/ Female
/ Food
/ Glucose
/ Humanities and Social Sciences
/ Male
/ Medulla Oblongata - cytology
/ Medulla Oblongata - physiology
/ Midline Thalamic Nuclei - cytology
/ Midline Thalamic Nuclei - physiology
/ Neurons
/ Nucleus Accumbens - cytology
/ Nucleus Accumbens - physiology
/ Science
/ Thalamus
