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An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation
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An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation
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Journal Article
An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation
2019
Overview
Bloodstream infections by
Salmonella enterica
serovar Typhimurium constitute a major health burden in sub-Saharan Africa (SSA). These invasive non-typhoidal (iNTS) infections are dominated by isolates of the antibiotic resistance-associated sequence type (ST) 313. Here, we report emergence of ST313 sublineage II.1 in the Democratic Republic of the Congo. Sublineage II.1 exhibits extensive drug resistance, involving a combination of multidrug resistance, extended spectrum β-lactamase production and azithromycin resistance. ST313 lineage II.1 isolates harbour an IncHI2 plasmid we name pSTm-ST313-II.1, with one isolate also exhibiting decreased ciprofloxacin susceptibility. Whole genome sequencing reveals that ST313 II.1 isolates have accumulated genetic signatures potentially associated with altered pathogenicity and host adaptation, related to changes observed in biofilm formation and metabolic capacity. Sublineage II.1 emerged at the beginning of the 21st century and is involved in on-going outbreaks. Our data provide evidence of further evolution within the ST313 clade associated with iNTS in SSA.
Invasive non-typhoidal
Salmonella
(iNTS) infections are dominated by antibiotic resistant isolates of the sequence type (ST) 313. Here, the authors identify the ST313 sublineage II.1 in the Democratic Republic of the Congo exhibiting extensive drug resistance and genetic signatures potentially associated with host adaptation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/70
/ 45
/ 45/23
/ 64/60
/ 706/134
/ Adaptation, Physiological - drug effects
/ Adaptation, Physiological - genetics
/ Animals
/ Anti-Bacterial Agents - pharmacology
/ Biofilms
/ Biofilms - growth & development
/ Ciprofloxacin - pharmacology
/ Democratic Republic of the Congo
/ Drug Resistance, Multiple, Bacterial - genetics
/ Genomes
/ Humanities and Social Sciences
/ Humans
/ Mice
/ Salmonella typhimurium - drug effects
/ Salmonella typhimurium - genetics
/ Salmonella typhimurium - isolation & purification
/ Science
