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Interferon-gamma regulates inflammatory cell death by targeting necroptosis in experimental autoimmune arthritis
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Interferon-gamma regulates inflammatory cell death by targeting necroptosis in experimental autoimmune arthritis
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Journal Article
Interferon-gamma regulates inflammatory cell death by targeting necroptosis in experimental autoimmune arthritis
2017
Overview
Interferon γ (IFN-γ) induces an inflammatory response and apoptotic cell death. Rheumatoid arthritis (RA) is a systemic inflammatory disease associated with increased levels of inflammatory mediators, including tumour necrosis factor α (TNF-α) and T helper (Th) 17 cells, and downregulation of apoptosis of inflammatory cells. We hypothesized that IFN-γ would reduce inflammatory cell death
in vitro
and that loss of IFN-γ would aggravate inflammation
in vivo
. IFN-γ downregulated necroptosis and the expression of cellular FLICE-like inhibitory protein (cFLIP
L
) and mixed lineage kinase domain-like (MLKL). However, loss of IFN-γ promoted the production of cFLIP
L
and MLKL, and necroptosis. IFN-γ deficiency increased Th17 cell number and upregulated the expression of IL-17 and TNF-α. Expression of MLKL, receptor interacting protein kinase (RIPK)1, and RIPK3 was increased in the joints of mice with collagen-induced arthritis (CIA). Compared with wild-type mice with CIA, IFN-γ
−/−
CIA mice showed exacerbation of cartilage damage and joint inflammation, and acceleration of MLKL, RIPK1, and RIPK3 production in the joints. IFN-γ deficiency induced the activation of signal transducer and activator of transcription 3. These results suggest that IFN-γ regulates inflammatory cell death and may have potential for use in the treatment of RA.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/21
/ 13/31
/ 13/51
/ 38/61
/ 64/600
/ Animals
/ Arthritis, Experimental - metabolism
/ CASP8 and FADD-Like Apoptosis Regulating Protein - genetics
/ CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism
/ Collagen
/ Humanities and Social Sciences
/ Interferon-gamma - metabolism
/ Kinases
/ Male
/ Mice
/ Protein Kinases - metabolism
/ Receptor-Interacting Protein Serine-Threonine Kinases - genetics
/ Receptor-Interacting Protein Serine-Threonine Kinases - metabolism
/ Science
/ Tumor Necrosis Factor-alpha - genetics
/ Tumor Necrosis Factor-alpha - metabolism
/ Tumors
