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Neural control of fasting-induced torpor in mice
by
Lo Martire, Viviana
, Berteotti, Chiara
, Hitrec, Timna
, Tupone, Domenico
, Cerri, Matteo
, Martelli, Davide
, Squarcio, Fabio
, Amici, Roberto
, Luppi, Marco
, Bastianini, Stefano
, Zoccoli, Giovanna
, Occhinegro, Alessandra
in
13/1
/ 14/63
/ 631/378/3920
/ 631/443/319/1557
/ 631/443/376
/ 64/60
/ 692/698/1688/1315
/ 692/698/1688/64
/ Adipose tissue
/ Adipose tissue (brown)
/ Animals
/ Body temperature
/ Body Temperature Regulation - physiology
/ c-Fos protein
/ Cholera toxin
/ Fasting
/ Hibernation
/ Humanities and Social Sciences
/ Hypothalamus (dorsomedial)
/ Hypothalamus - physiology
/ Metabolic rate
/ Mice
/ multidisciplinary
/ Neural Pathways - physiology
/ Science
/ Science (multidisciplinary)
/ Thermogenesis
/ Thermogenesis - physiology
/ Torpor
/ Toxins
/ Waterborne diseases
2019
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Neural control of fasting-induced torpor in mice
by
Lo Martire, Viviana
, Berteotti, Chiara
, Hitrec, Timna
, Tupone, Domenico
, Cerri, Matteo
, Martelli, Davide
, Squarcio, Fabio
, Amici, Roberto
, Luppi, Marco
, Bastianini, Stefano
, Zoccoli, Giovanna
, Occhinegro, Alessandra
in
13/1
/ 14/63
/ 631/378/3920
/ 631/443/319/1557
/ 631/443/376
/ 64/60
/ 692/698/1688/1315
/ 692/698/1688/64
/ Adipose tissue
/ Adipose tissue (brown)
/ Animals
/ Body temperature
/ Body Temperature Regulation - physiology
/ c-Fos protein
/ Cholera toxin
/ Fasting
/ Hibernation
/ Humanities and Social Sciences
/ Hypothalamus (dorsomedial)
/ Hypothalamus - physiology
/ Metabolic rate
/ Mice
/ multidisciplinary
/ Neural Pathways - physiology
/ Science
/ Science (multidisciplinary)
/ Thermogenesis
/ Thermogenesis - physiology
/ Torpor
/ Toxins
/ Waterborne diseases
2019
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Neural control of fasting-induced torpor in mice
by
Lo Martire, Viviana
, Berteotti, Chiara
, Hitrec, Timna
, Tupone, Domenico
, Cerri, Matteo
, Martelli, Davide
, Squarcio, Fabio
, Amici, Roberto
, Luppi, Marco
, Bastianini, Stefano
, Zoccoli, Giovanna
, Occhinegro, Alessandra
in
13/1
/ 14/63
/ 631/378/3920
/ 631/443/319/1557
/ 631/443/376
/ 64/60
/ 692/698/1688/1315
/ 692/698/1688/64
/ Adipose tissue
/ Adipose tissue (brown)
/ Animals
/ Body temperature
/ Body Temperature Regulation - physiology
/ c-Fos protein
/ Cholera toxin
/ Fasting
/ Hibernation
/ Humanities and Social Sciences
/ Hypothalamus (dorsomedial)
/ Hypothalamus - physiology
/ Metabolic rate
/ Mice
/ multidisciplinary
/ Neural Pathways - physiology
/ Science
/ Science (multidisciplinary)
/ Thermogenesis
/ Thermogenesis - physiology
/ Torpor
/ Toxins
/ Waterborne diseases
2019
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Journal Article
Neural control of fasting-induced torpor in mice
2019
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Overview
Torpor is a peculiar mammalian behaviour, characterized by the active reduction of metabolic rate, followed by a drop in body temperature. To enter torpor, the activation of all thermogenic organs that could potentially defend body temperature must be prevented. Most of these organs, such as the brown adipose tissue, are controlled by the key thermoregulatory region of the Raphe Pallidus (RPa). Currently, it is not known which brain areas mediate the entrance into torpor. To identify these areas, the expression of the early gene c-Fos at torpor onset was assessed in different brain regions in mice injected with a retrograde tracer (Cholera Toxin subunit b, CTb) into the RPa region. The results show a network of hypothalamic neurons that are specifically activated at torpor onset and a direct torpor-specific projection from the Dorsomedial Hypothalamus to the RPa that could putatively mediate the suppression of thermogenesis during torpor.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
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