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Stochastic pulsing of gene expression enables the generation of spatial patterns in Bacillus subtilis biofilms
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Stochastic pulsing of gene expression enables the generation of spatial patterns in Bacillus subtilis biofilms
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Journal Article
Stochastic pulsing of gene expression enables the generation of spatial patterns in Bacillus subtilis biofilms
2020
Overview
Stochastic pulsing of gene expression can generate phenotypic diversity in a genetically identical population of cells, but it is unclear whether it has a role in the development of multicellular systems. Here, we show how stochastic pulsing of gene expression enables spatial patterns to form in a model multicellular system,
Bacillus subtilis
bacterial biofilms. We use quantitative microscopy and time-lapse imaging to observe pulses in the activity of the general stress response sigma factor
σ
B
in individual cells during biofilm development. Both
σ
B
and sporulation activity increase in a gradient, peaking at the top of the biofilm, even though
σ
B
represses sporulation. As predicted by a simple mathematical model, increasing
σ
B
expression shifts the peak of sporulation to the middle of the biofilm. Our results demonstrate how stochastic pulsing of gene expression can play a key role in pattern formation during biofilm development.
Stochastic pulsing of gene expression can generate phenotypic diversity in a genetically identical population of cells. Here, the authors show that stochastic pulsing in the expression of a sigma factor enables the formation of spatial patterns in a multicellular system,
Bacillus subtilis
bacterial biofilms.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Bacillus subtilis - genetics
/ Bacillus subtilis - metabolism
/ Bacillus subtilis - physiology
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Biofilms
/ Biofilms - growth & development
/ Gene Expression Regulation, Bacterial
/ Humanities and Social Sciences
/ Science
/ Spores, Bacterial - genetics
/ Spores, Bacterial - metabolism
