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Alterations in promoter interaction landscape and transcriptional network underlying metabolic adaptation to diet
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Alterations in promoter interaction landscape and transcriptional network underlying metabolic adaptation to diet
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Alterations in promoter interaction landscape and transcriptional network underlying metabolic adaptation to diet
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Journal Article
Alterations in promoter interaction landscape and transcriptional network underlying metabolic adaptation to diet
2020
Overview
Metabolic adaptation to nutritional state requires alterations in gene expression in key tissues. Here, we investigated chromatin interaction dynamics, as well as alterations in cis-regulatory loci and transcriptional network in a mouse model system. Chronic consumption of a diet high in saturated fat, when compared to a diet high in carbohydrate, led to dramatic reprogramming of the liver transcriptional network. Long-range interaction of promoters with distal regulatory loci, monitored by promoter capture Hi-C, was regulated by metabolic status in distinct fashion depending on diet. Adaptation to a lipid-rich diet, mediated largely by nuclear receptors including Hnf4α, relied on activation of preformed enhancer/promoter loops. Adaptation to carbohydrate-rich diet led to activation of preformed loops and to de novo formation of new promoter/enhancer interactions. These results suggest that adaptation to nutritional changes and metabolic stress occurs through both de novo and pre-existing chromatin interactions which respond differently to metabolic signals.
Metabolic adaptation to different diets results in changes to gene expression. Here, the authors characterise the chromatin landscape and transcriptional network in mice on a diet of high saturated fat, compared to a diet high in carbohydrate, finding a dramatic reprogramming of the liver transcriptional network.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/91
/ 45
/ 45/15
/ 64
/ 64/60
/ 82/29
/ Animals
/ Chromatin Immunoprecipitation
/ Diet
/ Enhancer Elements, Genetic - genetics
/ Gene Regulatory Networks - genetics
/ Humanities and Social Sciences
/ Lipids
/ Liver
/ Loci
/ Male
/ Mice
/ Non-alcoholic Fatty Liver Disease - genetics
/ Non-alcoholic Fatty Liver Disease - metabolism
/ Promoter Regions, Genetic - genetics
/ Science
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