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Journal Article
Evaluation of selected IL6/STAT3 pathway molecules and miRNA expression in chronic obstructive pulmonary disease
2021
Overview
COPD has been regarded as a global epidemic due to an increase in pollution and tobacco exposure. Therefore, the study of molecular mechanism as the basis for modern therapy is important. The aim of the study was the assessment of gene expression levels,
IL-6
,
IL-6ST
,
PIAS3
,
STAT3
, and miRNAs, miRNA-1, miRNA-106b, miRNA-155, in patients with COPD. Induced sputum as well as PBMC were collected from 40 patients clinically verified according to the GOLD 2021 (A–D) classification and from the control group (n = 20). The levels of gene and miRNA expression were analysed by qPCR. In induced sputum
IL6
was significantly down-regulated in COPD group compared with control (
p
= 0.0008), while
IL6ST
were up-regulated (
p
= 0.05). The results were also statistically significant for
STAT3
(
p
= 0.04) and miRNA-155 (
p
= 0.03) with higher expression in the current smokers compared to ex-smokers. Higher expression levels for
IL6ST
(
p
= 0.03) in COPD patients with the exacerbation history compared to COPD patients without the exacerbation history were noted. Compared induced sputum and PB lymphocytes we observed higher expression of
IL6
(
p
= 0.0003)
, STAT3
(
p
= 0.000001) miRNA-106b (
p
= 0.000069 and miRNA-155 (
p
= 0.000016) in induced sputum with lower expression of
PIAS3
(
p
= 0.006),
IL6ST
(
p
= 0.002) and miRNA-1 (
p
= 0.001). Differences in gene expression levels of the IL-6/IL6ST/STAT3 pathway and miRNA depending on the smoking status and classification of patients according to GOLD suggest the importance of these genes in the pathogenesis of COPD and may indicate their potential utility in monitoring the course of the disease.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/4017
/ 692/53
/ 692/699
/ Aged
/ Chronic obstructive pulmonary disease
/ Female
/ Gold
/ Humanities and Social Sciences
/ Humans
/ Male
/ miRNA
/ Molecular Chaperones - genetics
/ Molecular Chaperones - metabolism
/ Peripheral blood mononuclear cells
/ Protein Inhibitors of Activated STAT - genetics
/ Protein Inhibitors of Activated STAT - metabolism
/ Pulmonary Disease, Chronic Obstructive - genetics
/ Pulmonary Disease, Chronic Obstructive - metabolism
/ Pulmonary Disease, Chronic Obstructive - pathology
/ Science
/ Sputum
/ STAT3 Transcription Factor - genetics
