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A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis
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A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis
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Journal Article
A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis
2021
Overview
Camptothecin and its derivatives are widely used for treating malignant tumors. Previous studies revealed only a limited number of candidate genes for camptothecin biosynthesis in
Camptotheca acuminata
, and it is still poorly understood how its biosynthesis of camptothecin has evolved. Here, we report a high-quality, chromosome-level
C
.
acuminata
genome assembly. We find that
C
.
acuminata
experiences an independent whole-genome duplication and numerous genes derive from it are related to camptothecin biosynthesis. Comparing with
Catharanthus roseus
, the loganic acid
O
-methyltransferase (LAMT) in
C. acuminata
fails to convert loganic acid into loganin. Instead, two secologanic acid synthases (SLASs) convert loganic acid to secologanic acid. The functional divergence of the
LAMT
gene and positive evolution of two
SLAS
genes, therefore, both contribute greatly to the camptothecin biosynthesis in
C. acuminata
. Our results emphasize the importance of high-quality genome assembly in identifying genetic changes in the evolutionary origin of a secondary metabolite.
Camptothecin is a monoterpene indole alkaloid with anti-tumor activity. Here, the authors assemble the genome of the camptothecin producing plant
Camptotheca acuminata
and provide insights into the evolutionary origin of camptothecin biosynthesis by comparing to the vinblastine and vincristine biosynthetic pathway in
Catharanthus roseus
.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/77
/ 82/80
/ Acids
/ Assembly
/ Cytochrome P-450 Enzyme System
/ Gene Expression Regulation, Plant - genetics
/ Genes
/ Genomes
/ Genomics
/ Humanities and Social Sciences
/ Indoles
/ Oxidoreductases Acting on CH-CH Group Donors
/ Protein O-Methyltransferase - genetics
/ Protein O-Methyltransferase - metabolism
/ RNA-Seq
/ Science
/ Secondary Metabolism - genetics
/ Tumors
