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Cancer cells with trapped nuclei cut their way through the extracellular matrix
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Journal Article
Cancer cells with trapped nuclei cut their way through the extracellular matrix
2018
Overview
When an invading cancer cell attempts to pass through a hole in the extracellular matrix (ECM) which is too small for its nucleus, this generates physical tension. This tension is sensed by a nucleus–centrosome connection that activates trafficking of endosomal vesicles containing the matrix metalloprotease, MT1-MMP1 to the site of constraint. Recent evidence shows how focussed ECM degradation relieves the constraint and allows cancer cells to continue invading.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
