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Novel Mechanism of the Pericyte-Myofibroblast Transition in Renal Interstitial Fibrosis: Core Fucosylation Regulation
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Novel Mechanism of the Pericyte-Myofibroblast Transition in Renal Interstitial Fibrosis: Core Fucosylation Regulation
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Journal Article
Novel Mechanism of the Pericyte-Myofibroblast Transition in Renal Interstitial Fibrosis: Core Fucosylation Regulation
2017
Overview
Pericytes have been identified as a major source of myofibroblasts in renal interstitial fibrosis (RIF). The overactivation of several signaling pathways, mainly the TGF-β and PDGF pathways, initiates the pericyte-myofibroblast transition during RIF. Key receptors in these two pathways have been shown to be modified by fucosyltransferase 8 (FUT8), the enzyme that catalyzes core fucosylation. This study postulated that core fucosylation might play an important role in regulating the pericyte transition in RIF. The data showed that core fucosylation increased with the extent of RIF in patients with IgA nephropathy (IgAN). Similarly, core fucosylation of pericytes increased in both a unilateral ureteral occlusion (UUO) mouse model and an
in vitro
model of pericyte transition. Inhibition of core fucosylation by adenoviral-mediated
FUT8
shRNA
in vivo
and
FUT8
siRNA
in vitro
significantly reduced pericyte transition and RIF. In addition, the activation of both the TGF-β/Smad and PDGF/ERK pathways was blocked by core fucosylation inhibition. In conclusion, core fucosylation may regulate the pericyte transition in RIF by modifying both the TGF-β/Smad and PDGF/ERK pathways. Glycosylation might be a novel “hub” target to prevent RIF.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/21
/ Adult
/ Animals
/ Female
/ Fibrosis
/ Fucosyltransferases - genetics
/ Fucosyltransferases - metabolism
/ Glomerulonephritis, IGA - pathology
/ Humanities and Social Sciences
/ Humans
/ Kidney Diseases - metabolism
/ Kidneys
/ Male
/ Platelet-derived growth factor
/ Platelet-Derived Growth Factor - metabolism
/ Receptors, Transforming Growth Factor beta - metabolism
/ Rodents
/ Science
/ siRNA
