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Neural precursor cells tune striatal connectivity through the release of IGFBPL1
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Neural precursor cells tune striatal connectivity through the release of IGFBPL1
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Journal Article
Neural precursor cells tune striatal connectivity through the release of IGFBPL1
2022
Overview
The adult brain retains over life endogenous neural stem/precursor cells (eNPCs) within the subventricular zone (SVZ). Whether or not these cells exert physiological functions is still unclear. In the present work, we provide evidence that SVZ-eNPCs tune structural, electrophysiological, and behavioural aspects of striatal function via secretion of insulin-like growth factor binding protein-like 1 (IGFBPL1). In mice, selective ablation of SVZ-eNPCs or selective abrogation of IGFBPL1 determined an impairment of striatal medium spiny neuron morphology, a higher failure rate in GABAergic transmission mediated by fast-spiking interneurons, and striatum-related behavioural dysfunctions. We also found IGFBPL1 expression in the human SVZ, foetal and induced-pluripotent stem cell-derived NPCs. Finally, we found a significant correlation between SVZ damage, reduction of striatum volume, and impairment of information processing speed in neurological patients. Our results highlight the physiological role of adult SVZ-eNPCs in supporting cognitive functions by regulating striatal neuronal activity.
The physiological role of endogenous neural protenitor cells of the subventricular zone in adult stage is not fully understood. Here the authors show that in mice, these cells tune neuronal activity of the striatum via insulin-like growth factor binding protein-like 1 and cognitive functions.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/51
/ 14/19
/ 14/28
/ 38/91
/ 45/77
/ 45/90
/ 631/378
/ Ablation
/ Animals
/ Humanities and Social Sciences
/ Humans
/ Insulin
/ Insulin-Like Growth Factor Binding Proteins - physiology
/ Lateral Ventricles - physiology
/ Mice
/ Neural Stem Cells - physiology
/ Proteins
/ Science
