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Diacetylmorphine versus Methadone for the Treatment of Opioid Addiction
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Diacetylmorphine versus Methadone for the Treatment of Opioid Addiction
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Journal Article
Diacetylmorphine versus Methadone for the Treatment of Opioid Addiction
2009
Overview
In this 12-month randomized trial involving 251 long-term heroin users, injectable diacetylmorphine (the active ingredient in heroin) was more effective than oral methadone in achieving retention in treatment for addiction and in reducing illicit-drug use and other illegal activity. As compared with methadone, injectable diacetylmorphine was associated with more serious adverse events, including seizures and drug overdoses.
In long-term heroin users, injectable diacetylmorphine (the active ingredient in heroin) was more effective than oral methadone in achieving retention in treatment for addiction and in reducing illicit-drug use and other illegal activity.
Opioid dependence, most commonly manifested as heroin dependence, is a chronic relapsing condition
1
that is estimated to affect more than 1 million persons in North America.
2
,
3
The risks of opioid dependence include fatal overdoses, infections (including endocarditis, human immunodeficiency virus infection, and hepatitis C virus infection), social disintegration, violence, and crime. The associated burdens on communities include medical, public health, and criminal-justice costs as well as public disorder and crimes against property.
Methadone, the standard opioid-substitution treatment, has been shown to reduce major risks associated with untreated opioid dependence in patients who are willing to undergo and are successfully . . .
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Adult and adolescent clinical studies
/ Biological and medical sciences
/ Cocaine-Related Disorders - epidemiology
/ Drugs
/ Female
/ Heroin
/ Heroin - administration & dosage
/ Heroin Dependence - drug therapy
/ Heroin Dependence - epidemiology
/ Humans
/ Hydromorphone - adverse effects
/ Hydromorphone - therapeutic use
/ Male
/ Methadone - administration & dosage
