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Ontogeny and function of murine epidermal Langerhans cells
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Ontogeny and function of murine epidermal Langerhans cells
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Journal Article
Ontogeny and function of murine epidermal Langerhans cells
2017
Overview
Kaplan reviews the development of skin-resident Langerhans cells and their unique functional roles that distinguish these cells from other skin antigen-presenting cells.
Langerhans cells (LCs) are epidermis-resident antigen-presenting cells that share a common ontogeny with macrophages but function as dendritic cells (DCs). Their development, recruitment and retention in the epidermis is orchestrated by interactions with keratinocytes through multiple mechanisms. LC and dermal DC subsets often show functional redundancy, but LCs are required for specific types of adaptive immune responses when antigen is concentrated in the epidermis. This Review will focus on those developmental and functional properties that are unique to LCs.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Antigen-Presenting Cells - immunology
/ Antigen-Presenting Cells - metabolism
/ Antigens
/ Biomedical and Life Sciences
/ Dendritic Cells - immunology
/ Dendritic Cells - metabolism
/ Langerhans Cells - immunology
/ Langerhans Cells - metabolism
/ Mice
/ Ontogeny
/ Skin
