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Impact of maternal and offspring smoking and breastfeeding on oesophageal cancer in adult offspring
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Impact of maternal and offspring smoking and breastfeeding on oesophageal cancer in adult offspring
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Journal Article
Impact of maternal and offspring smoking and breastfeeding on oesophageal cancer in adult offspring
2025
Overview
Numerous risk factors for oesophageal cancer are linked to lifestyle habits, but the role of early-life factors in its incidence and mortality is unclear. Using UK Biobank data, we explore the association among breastfeeding, maternal smoking, smoking in offspring, and oesophageal cancer risk in adult offspring via multivariable Cox regression. Here, we show that being breastfed, compared with not being breastfed, is associated with a lower risk of oesophageal cancer incidence (HR: 0.83, 95% CI: 0.70–0.98) and mortality (HR: 0.74, 95% CI: 0.61–0.89) in adult offspring. Additionally, it is associated with a reduced impact of smoking in offspring on oesophageal cancer incidence (HR: 0.79, 95% CI: 0.64-0.96) and mortality (HR: 0.73, 95% CI: 0.59-0.91). We subsequently construct a polygenic risk score for oesophageal cancer to explore the influence of genetic factors. Our findings emphasize the importance of breastfeeding, and smoking cessation to prevent oesophageal cancer.
Early life factors like breastfeeding and maternal smoking may influence oesophageal cancer risk in adults. Here, the authors analyse data from the UK biobank and show that breastfeeding is associated with reduced incidence and mortality of oesophageal cancer and reduced adverse effects of smoking in offspring.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Adult
/ Adult Children - statistics & numerical data
/ Aged
/ Biobanks
/ Breast Feeding - statistics & numerical data
/ Cancer
/ Esophageal Neoplasms - epidemiology
/ Esophageal Neoplasms - etiology
/ Esophageal Neoplasms - genetics
/ Esophageal Neoplasms - mortality
/ Female
/ Humanities and Social Sciences
/ Humans
/ Male
/ Science
/ Smoking
