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APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease
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APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease
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Journal Article
APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease
2013
Overview
In this study,
APOL1
variants were associated with an increased risk of progression of chronic kidney disease in black patients, as compared with white patients, regardless of the cause of kidney disease or diabetes status.
In the United States, black patients have approximately twice the risk of end-stage renal disease observed among white patients, after accounting for differences in socioeconomic and clinical risk factors.
1
–
4
This increased risk occurs despite a similar prevalence in earlier stages of chronic kidney disease
5
–
8
in the two racial groups, which suggests that kidney function declines more rapidly after the onset of chronic kidney disease in black patients. However, there is little direct evidence in support of this hypothesis.
9
–
13
The identification of factors that mediate differences in the progression of chronic kidney disease between black patients and white . . .
Publisher
Massachusetts Medical Society
Subject
/ African Americans - genetics
/ Aged
/ Biological and medical sciences
/ Diabetes
/ Diabetes Complications - genetics
/ Epidermal growth factor receptors
/ European Continental Ancestry Group - genetics
/ Female
/ Genetic Predisposition to Disease
/ Humans
/ Hypertension - complications
/ Kidney Failure, Chronic - ethnology
/ Kidney Failure, Chronic - genetics
/ Kidneys
/ Lipoproteins, HDL - genetics
/ Male
/ Nephrology. Urinary tract diseases
/ Nephropathies. Renovascular diseases. Renal failure
/ Polymorphism, Single Nucleotide
/ Renal Insufficiency, Chronic - ethnology
/ Renal Insufficiency, Chronic - genetics
/ Urinary system involvement in other diseases. Miscellaneous
