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The development of a bioengineered organ germ method
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Journal Article
The development of a bioengineered organ germ method
2007
Overview
To bioengineer ectodermal organs such as teeth and whisker follicles, we developed a three-dimensional organ-germ culture method. The bioengineered tooth germ generated a structurally correct tooth, after both
in vitro
organ culture as well as transplantation under a tooth cavity
in vivo
, showing penetration of blood vessels and nerve fibers. Our method provides a substantial advance in the development of bioengineered organ replacement strategies and regenerative therapies.
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Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Biomedical and Life Sciences
/ Biomedical Engineering - methods
/ Biomedical Engineering/Biotechnology
/ Epithelial Cells - physiology
/ Fibers
/ Mesenchymal Stromal Cells - cytology
/ Methods
/ Mice
/ Organ Culture Techniques - methods
/ Skin
/ Teeth
/ Tissue Engineering - methods
