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Hypothalamic melanin-concentrating hormone neurons integrate food-motivated appetitive and consummatory processes in rats
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Hypothalamic melanin-concentrating hormone neurons integrate food-motivated appetitive and consummatory processes in rats
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Hypothalamic melanin-concentrating hormone neurons integrate food-motivated appetitive and consummatory processes in rats
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Journal Article
Hypothalamic melanin-concentrating hormone neurons integrate food-motivated appetitive and consummatory processes in rats
2023
Overview
The lateral hypothalamic area (LHA) integrates homeostatic processes and reward-motivated behaviors. Here we show that LHA neurons that produce melanin-concentrating hormone (MCH) are dynamically responsive to both food-directed appetitive and consummatory processes in male rats. Specifically, results reveal that MCH neuron Ca
2+
activity increases in response to both discrete and contextual food-predictive cues and is correlated with food-motivated responses. MCH neuron activity also increases during eating, and this response is highly predictive of caloric consumption and declines throughout a meal, thus supporting a role for MCH neurons in the positive feedback consummatory process known as appetition. These physiological MCH neural responses are functionally relevant as chemogenetic MCH neuron activation promotes appetitive behavioral responses to food-predictive cues and increases meal size. Finally, MCH neuron activation enhances preference for a noncaloric flavor paired with intragastric glucose. Collectively, these data identify a hypothalamic neural population that orchestrates both food-motivated appetitive and intake-promoting consummatory processes.
Food intake is determined by learned appetitive responses and physiological “appetition” signals after eating begins. Here, authors show melanin-concentrating hormone (MCH)-producing neurons integrate these processes to promote caloric intake.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/51
/ 14/35
/ 14/63
/ 96
/ Animals
/ Eating
/ Flavors
/ Food
/ Humanities and Social Sciences
/ Hypothalamic Area, Lateral - metabolism
/ Hypothalamic Hormones - metabolism
/ Male
/ Melanin
/ Melanin-concentrating hormone
/ Melanins
/ Neurons
/ Rats
/ Science
