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Comparative membrane proteomic analysis of Tritrichomonas foetus isolates
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Comparative membrane proteomic analysis of Tritrichomonas foetus isolates
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Comparative membrane proteomic analysis of Tritrichomonas foetus isolates
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Journal Article
Comparative membrane proteomic analysis of Tritrichomonas foetus isolates
2024
Overview
Tritrichomonas foetus
is a flagellated and anaerobic parasite able to infect cattle and felines. Despite its prevalence, there is no effective standardized or legal treatment for
T. foetus-
infected cattle; the vaccination still has limited success in mitigating infections and reducing abortion risk; and nowadays, the diagnosis of
T. foetus
presents important limitations in terms of sensitivity and specificity in bovines. Here, we characterize the plasma membrane proteome of
T. foetus
and identify proteins that are represented in different isolates of this protozoan. Additionally, we performed a bioinformatic analysis that revealed the antigenicity potential of some of those proteins. This analysis is the first study to identify common proteins at the plasma membrane of different
T. foetus
isolates that could be targets for alternative diagnostic or vaccine techniques in the future.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/61
/ Animals
/ Antigens
/ Cattle
/ Cattle Diseases - parasitology
/ Computational Biology - methods
/ Fetuses
/ Humanities and Social Sciences
/ Membrane Proteins - metabolism
/ Plasma
/ Proteins
/ Protozoan Infections, Animal - diagnosis
/ Protozoan Infections, Animal - parasitology
/ Protozoan Proteins - analysis
/ Protozoan Proteins - metabolism
/ Science
/ Tritrichomonas foetus - isolation & purification
/ Tritrichomonas foetus isolates
/ Vaccines
