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Characterization of the gut bacterial and viral microbiota in latent autoimmune diabetes in adults
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Characterization of the gut bacterial and viral microbiota in latent autoimmune diabetes in adults
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Journal Article
Characterization of the gut bacterial and viral microbiota in latent autoimmune diabetes in adults
2024
Overview
Latent autoimmune diabetes in adults (LADA) is a heterogeneous disease characterized by autoantibodies against insulin producing pancreatic beta cells and initial lack of need for insulin treatment. The aim of the present study was to investigate if individuals with LADA have an altered gut microbiota relative to non-diabetic control subjects, individuals with type 1 diabetes (T1D), and individuals with type 2 diabetes (T2D). Bacterial community profiling was performed with primers targeting the variable region 4 of the 16S rRNA gene and sequenced. Amplicon sequence variants (ASVs) were generated with DADA2 and annotated to the SILVA database. The gut virome was sequenced, using a viral particle enrichment and metagenomics approach, assembled, and quantified to describe the composition of the viral community. Comparison of the bacterial alpha- and beta-diversity measures revealed that the gut bacteriome of individuals with LADA resembled that of individuals with T2D. Yet, specific genera were found to differ in abundance in individuals with LADA compared with T1D and T2D, indicating that LADA has unique taxonomical features. The virome composition reflected the stability of the most dominant order
Caudovirales
and the families
Siphoviridae
,
Podoviridae
, and
Inoviridae
, and the dominant family
Microviridae
. Further studies are needed to confirm these findings.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Adult
/ Bacteria
/ Diabetes
/ Diabetes mellitus (insulin dependent)
/ Diabetes mellitus (non-insulin dependent)
/ Diabetes Mellitus, Type 1 - genetics
/ Diabetes Mellitus, Type 2 - genetics
/ Gastrointestinal Microbiome - genetics
/ Genera
/ Humanities and Social Sciences
/ Humans
/ Insulin
/ Intercellular Signaling Peptides and Proteins
/ Latent Autoimmune Diabetes in Adults - genetics
/ RNA, Ribosomal, 16S - genetics
/ rRNA 16S
/ Science
