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Alcohol consumption and risks of more than 200 diseases in Chinese men
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Journal Article
Alcohol consumption and risks of more than 200 diseases in Chinese men
2023
Overview
Alcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol consumption with 207 diseases in the 12-year China Kadoorie Biobank of >512,000 adults (41% men), including 168,050 genotyped for
ALDH2
-
rs671
and
ADH1B
-
rs1229984
, with >1.1 million ICD-10 coded hospitalized events. At baseline, 33% of men drank alcohol regularly. Among men, alcohol intake was positively associated with 61 diseases, including 33 not defined by the World Health Organization as alcohol-related, such as cataract (
n
= 2,028; hazard ratio 1.21; 95% confidence interval 1.09–1.33, per 280 g per week) and gout (
n
= 402; 1.57, 1.33–1.86). Genotype-predicted mean alcohol intake was positively associated with established (
n
= 28,564; 1.14, 1.09–1.20) and new alcohol-associated (
n
= 16,138; 1.06, 1.01–1.12) diseases, and with specific diseases such as liver cirrhosis (
n
= 499; 2.30, 1.58–3.35), stroke (
n
= 12,176; 1.38, 1.27–1.49) and gout (
n
= 338; 2.33, 1.49–3.62), but not ischemic heart disease (
n
= 8,408; 1.04, 0.94–1.14). Among women, 2% drank alcohol resulting in low power to assess associations of self-reported alcohol intake with disease risks, but genetic findings in women suggested the excess male risks were not due to pleiotropic genotypic effects. Among Chinese men, alcohol consumption increased multiple disease risks, highlighting the need to strengthen preventive measures to reduce alcohol intake.
Observational analyses from the China Kadoorie Biobank found that alcohol consumption was associated with higher risks of 61 diseases in Chinese men, with most of these associations confirmed by genetic analyses.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 692/499
/ Adult
/ Alcohol Drinking - adverse effects
/ Alcohol Drinking - epidemiology
/ Alcohol Drinking - ethnology
/ Alcohols
/ Aldehyde Dehydrogenase, Mitochondrial - genetics
/ Biobanks
/ Biomedical and Life Sciences
/ East Asian People - statistics & numerical data
/ Ethanol
/ Female
/ Genotype
/ Gout
/ Humans
/ Ischemia
/ Male
/ Men
/ Women
