Asset Details
Do you wish to reserve the book?
Single-cell analysis identifies the CNP/GC-B/cGMP axis as marker and regulator of modulated VSMCs in atherosclerosis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Single-cell analysis identifies the CNP/GC-B/cGMP axis as marker and regulator of modulated VSMCs in atherosclerosis
Do you wish to request the book?
Single-cell analysis identifies the CNP/GC-B/cGMP axis as marker and regulator of modulated VSMCs in atherosclerosis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Single-cell analysis identifies the CNP/GC-B/cGMP axis as marker and regulator of modulated VSMCs in atherosclerosis
2025
Overview
A balanced activity of cGMP signaling contributes to the maintenance of cardiovascular homeostasis. Vascular smooth muscle cells (VSMCs) can generate cGMP via three ligand-activated guanylyl cyclases, the NO-sensitive guanylyl cyclase, the atrial natriuretic peptide (ANP)-activated GC-A, and the C-type natriuretic peptide (CNP)-stimulated GC-B. Here, we study natriuretic peptide signaling in murine VSMCs and atherosclerotic lesions. Correlative profiling of pathway activity and VSMC phenotype at the single-cell level shows that phenotypic modulation of contractile VSMCs to chondrocyte-like plaque cells during atherogenesis is associated with a switch from ANP/GC‑A to CNP/GC‑B signaling. Silencing of the CNP/GC-B axis in VSMCs results in an increase of chondrocyte-like plaque cells. These findings indicate that the CNP/GC-B/cGMP pathway is a marker and atheroprotective regulator of modulated VSMCs, limiting their transition to chondrocyte-like cells. Overall, this study highlights the plasticity of cGMP signaling in VSMCs and suggests analogies between CNP-dependent remodeling of bone and blood vessels.
The second messenger 3’,5’-cyclic guanosine monophosphate (cGMP) is important for the maintenance of cardiovascular homeostasis. Here, correlative single-cell profiling of cGMP dynamics and vascular cell phenotype reveals a druggable atheroprotective mechanism and suggests parallels between remodeling processes in bone and atherosclerotic arteries.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14
/ 14/10
/ 14/33
/ 14/63
/ 38/39
/ 49/91
/ 64/110
/ 96/1
/ 96/95
/ Animals
/ Arteries
/ Atherosclerosis - metabolism
/ Humanities and Social Sciences
/ Male
/ Mice
/ Muscle, Smooth, Vascular - cytology
/ Muscle, Smooth, Vascular - metabolism
/ Muscle, Smooth, Vascular - pathology
/ Myocytes, Smooth Muscle - metabolism
/ Myocytes, Smooth Muscle - pathology
/ Natriuretic Peptide, C-Type - genetics
/ Natriuretic Peptide, C-Type - metabolism
/ Peptides
/ Receptors, Atrial Natriuretic Factor - genetics
/ Receptors, Atrial Natriuretic Factor - metabolism
/ Science
