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Association of killer cell immunoglobulin-like receptors and their cognate HLA class I ligands with susceptibility to acute myeloid leukemia in Iranian patients
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Association of killer cell immunoglobulin-like receptors and their cognate HLA class I ligands with susceptibility to acute myeloid leukemia in Iranian patients
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Journal Article
Association of killer cell immunoglobulin-like receptors and their cognate HLA class I ligands with susceptibility to acute myeloid leukemia in Iranian patients
2023
Overview
Acute myeloid leukemia (AML) is one of the most prevalent leukemia in adults. Among the various NK receptors, killer immunoglobulin-like receptors (KIRs) carry out indispensable roles in NK cell development and function through engaging with class I human leukocyte antigens (HLA-I) as their ligands. Besides divergent KIR and HLA loci, KIR
/
HLA-I combinations have a significant effect on NK cell response. In this case–control study, we aimed to verify the association of KIR
/
HLA-I combinations with susceptibility to AML in the Southwestern Iranian population. KIR and HLA genotyping was performed with PCR-SSP by some novel primers for 181 patients with AML and 181 healthy controls. According to our results, the frequencies of KIR3DS1 (
p
= 0.0001, OR = 2.32, 95% CI 1.51–3.58), KIR2DS4fl (
p
= 0.02, OR = 1.53, 95% CI 1.05–2.21), CxT4 genotypes (
p
= 0.03, OR = 2.0, 95% CI 1.05–3.82), and T4 gene cluster (
p
= 0.01, OR = 1.99, 95% CI 1.17–3.41) were significantly higher in patients than controls, while C1/C2 genotype (
p
= 0.00002, OR = 0.39, 95% CI 0.25–0.61), HLA-A Bw4 (
p
= 0.02, OR = 0.6, 95% CI 0.38–0.94), and HLA-A*11 (
p
= 0.03, OR = 0.57, 95% CI 0.34–0.95) alleles were more frequent in controls. In addition, inhibitory (i)KIR
/
HLA-I combinations analysis revealed higher frequencies of KIR2DL1( +)
/
HLA-C2( +), KIR2DL2/3( +)
/
HLA-C1( +), KIR3DL1( +)
/
HLA-A Bw4( +), and KIR3DL2( +)
/
HLA-A*03/11( +) in the control group (
p
= 0.002, OR = 0.49, 95% CI 0.3–0.78;
p
= 0.04, OR = 0.62, 95% CI 0.39–0.99;
p
= 0.04, OR = 0.63, 95% CI 0.4–0.99; and
p
= 0.03, OR = 0.62, 95% CI 0.4–0.95, respectively). Overall, the number of iKIR
/
HLA-I combinations was more in the control group. Moreover, KIR3DS1( +)
/
HLA-B Bw4
Ile80
( +) and the sum of HLA-B Bw4/A Bw4 combined with KIR3DS1 as activating KIR
/
HLA-I combinations were more frequent among patients than controls (
p
= 0.01, OR = 1.99, 95% CI 1.14–3.49 and
p
= 0.005, OR = 1.97, 95% CI 1.22–3.19, respectively). In conclusion, our results postulate that inhibitory combinations play a protective role against AML by developing potent NK cells during education. It is noteworthy that KIR
/
HLA-I combination studies can be applicable in donor selection for allogeneic NK cell therapy in hematological malignancies.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
