Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages

by Paules, Richard S , Hung, Putzer J , Sleckman, Barry P , Morales, Abigail J , Calderon, Boris , Payton, Jacqueline E , Andrews, Jared M , Innes, Cynthia L , Carrero, Javier A , Tubbs, Anthony T , Edelson, Brian T

in Animals / Bone marrow / Cell activation / Cell cycle / Deoxyribonucleic acid / DNA / DNA Breaks, Double-Stranded / DNA Damage / DNA damage responses / DNA-dependent protein kinase / Environmental health / Gene expression / Gene Expression Regulation / Genetic diversity / Genomes / Genotoxicity / Health sciences / Immune response / Immunity, Innate / Immunology / Infections / inflammasome / Inflammasomes / Inflammasomes - metabolism / Innate immunity / Interferon / Interferon Type I - metabolism / Interleukin 18 / Intermediates / Kinases / Listeria monocytogenes / Listeria monocytogenes - immunology / macrophage / Macrophages / Macrophages - immunology / Mice / Pathogens / Protein kinase C / Protein Kinases - metabolism / Reactive nitrogen species / Reactive oxygen species / Type I IFN / γ-Interferon

2017

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages

2017

Confirm

Do you wish to request the book?

A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages

2017

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages

Paules, Richard S,

Hung, Putzer J,

Sleckman, Barry P,

Morales, Abigail J,

Calderon, Boris,

Payton, Jacqueline E,

Andrews, Jared M,

Innes, Cynthia L,

Carrero, Javier A,

Tubbs, Anthony T,

Edelson, Brian T

2017

Overview

Macrophages produce genotoxic agents, such as reactive oxygen and nitrogen species, that kill invading pathogens. Here we show that these agents activate the DNA damage response (DDR) kinases ATM and DNA-PKcs through the generation of double stranded breaks (DSBs) in murine macrophage genomic DNA. In contrast to other cell types, initiation of this DDR depends on signaling from the type I interferon receptor. Once activated, ATM and DNA-PKcs regulate a genetic program with diverse immune functions and promote inflammasome activation and the production of IL-1β and IL-18. Indeed, following infection with Listeria monocytogenes, DNA-PKcs-deficient murine macrophages produce reduced levels of IL-18 and are unable to optimally stimulate IFN-γ production by NK cells. Thus, genomic DNA DSBs act as signaling intermediates in murine macrophages, regulating innate immune responses through the initiation of a type I IFN-dependent DDR.

Share this book

Add to My Shelf

Publisher

eLife Science Publications, Ltd,eLife Sciences Publications Ltd,eLife Sciences Publications, Ltd

Subject

/ Deoxyribonucleic acid

/ DNA

/ DNA Breaks, Double-Stranded