Journal Article

Tuberculosis treatment outcomes and associated factors among tuberculosis patients treated at healthcare facilities of Motta Town, Northwest Ethiopia: a five-year retrospective study

Mitku, Melese Legesse, Fenta, Eneyew Talie, Sendekie, Ashenafi Kibret, Melese, Mihret, Limenh, Liknaw Workie, Ayenew, Wondim, Seid, Abdulwase Mohammed, Workye, Mulualem, Simegn, Wudneh, Kasahun, Asmamaw Emagn

2024

Overview

Tuberculosis (TB) remains a significant public health concern, particularly in low-resource settings. The treatment outcome is a crucial indicator of the effectiveness of TB treatment programs. Assessing the current treatment outcome and its associated factors is essential for improving patient care and reducing the spread of TB. Therefore, this study aimed to assess TB treatment outcomes and their associated factors among TB patients who received treatment at public healthcare facilities in Motta Town, Northwest Ethiopia. A facility-based retrospective cross-sectional study design was employed in two TB treatment centers in Motta town from January 2017 to December 2021. The study participants were all patients diagnosed with TB who received treatment. A p -value of 0.05 with a 95% confidence interval (CI) was used to determine statistical significance. A total of 362 TB patients were included in the study. The overall treatment success rate was 88.4% (95% CI 85.1, 91.7). Male gender (AOR = 2.40, 95% CI 1.16, 4.98), normal nutritional status (AOR = 3.11, 95% CI 1.33, 7.25), HIV negative status (AOR = 3.35, 95% CI 1.31, 8.60), and non-presumptive drug resistance to TB (AOR = 3.72, 95% CI 1.74, 7.98) were significantly associated with successful TB treatment outcomes ( p  < 0.05). In the current study, nine out of ten study participants had successful TB treatment outcome rates. Male gender, normal nutritional status, non-presumed drug resistance to TB, and HIV-negative status were significantly associated with successful TB treatment outcomes. By taking risk factors associated with poor treatment outcomes like those found in this study into account, patient management and treatment can be optimized. Sufficient TB control measures for populations are imperative and could significantly reduce the nation's total TB burden.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 631/326 / 692/308 / Antitubercular Agents - therapeutic use / Associated factors / Clinical outcomes / Cross-Sectional Studies / Delivery of Health Care / Drug resistance / Ethiopia - epidemiology / Gender / Health care / Health facilities / HIV / HIV Infections - drug therapy / Human immunodeficiency virus / Humanities and Social Sciences / Humans / Male / Motta town / multidisciplinary / Nutritional status / Patients / Public health / Retrospective Studies / Retrospective study / Risk factors / Science / Science (multidisciplinary) / Treatment Outcome / Treatment outcomes / Tuberculosis / Tuberculosis - complications / Tuberculosis - drug therapy / Tuberculosis - epidemiology