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Synergistic effects of thermally reduced graphene oxide/zinc oxide composite material on microbial infection for wound healing applications
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Synergistic effects of thermally reduced graphene oxide/zinc oxide composite material on microbial infection for wound healing applications
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Journal Article
Synergistic effects of thermally reduced graphene oxide/zinc oxide composite material on microbial infection for wound healing applications
2024
Overview
Infections originating from pathogenic microorganisms can significantly impede the natural wound-healing process. To address this obstacle, innovative bio-active nanomaterials have been developed to enhance antibacterial capabilities. This study focuses on the preparation of nanocomposites from thermally reduced graphene oxide and zinc oxide (TRGO/ZnO). The hydrothermal method was employed to synthesize these nanocomposites, and their physicochemical properties were comprehensively characterized using X-ray diffraction analysis
(
XRD
)
, High-resolution transmission electron microscopy (HR-TEM), Fourier-transform infrared (FT-IR), Raman spectroscopy, UV-vis, and field-emission scanning electron microscopy (FE-SEM) techniques. Subsequently, the potential of TRGO/ZnO nanocomposites as bio-active materials against wound infection-causing bacteria, including
Staphylococcus aureus
,
Pseudomonas aeruginosa
, and
Escherichia coli
, was evaluated. Furthermore, the investigated samples show disrupted bacterial biofilm formation. A reactive oxygen species (ROS) assay was conducted to investigate the mechanism of nanocomposite inhibition against bacteria and for further in-vivo determination of antimicrobial activity. The MTT assay was performed to ensure the safety and biocompatibility of nanocomposite. The results suggest that TRGO/ZnO nanocomposites have the potential to serve as effective bio-active nanomaterials for combating pathogenic microorganisms present in wounds.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 639/301
/ Animals
/ Anti-Bacterial Agents - chemistry
/ Anti-Bacterial Agents - pharmacology
/ Biofilms
/ E coli
/ Escherichia coli - drug effects
/ Graphene
/ Humanities and Social Sciences
/ Humans
/ Pseudomonas aeruginosa - drug effects
/ Reactive Oxygen Species - metabolism
/ Scanning electron microscopy
/ Science
/ Spectroscopy, Fourier Transform Infrared
/ Staphylococcus aureus - drug effects
/ Transmission electron microscopy
/ Wound Healing - drug effects
/ Wound Infection - drug therapy
