Journal Article

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

Ghetti, Bernardino, Goate, Alison, Fox, Nick C, Bateman, Randall J, Masters, Colin L, Morris, John C, Xiong, Chengjie, Klunk, William E, Benzinger, Tammie L.S, Mayeux, Richard, Buckles, Virginia, Salloway, Stephen, Moulder, Krista, Schofield, Peter R, Rossor, Martin N, Ringman, John M, Blazey, Tyler M, Aisen, Paul S, Marcus, Daniel S, Santacruz, Anna, Martins, Ralph N, Xie, Xianyun, Fagan, Anne M, Cairns, Nigel J, Holtzman, David M, McDade, Eric, Oliver, Angela, Sperling, Reisa A

2012

Overview

In this study of a cohort of adults with genetic mutations that cause autosomal dominant Alzheimer's disease, researchers identified abnormalities in cerebrospinal fluid biomarkers and neuroimaging tests that develop decades before the onset of dementia. Alzheimer's disease is the most common cause of dementia and is currently estimated to affect more than 5 million people in the United States, with an expected increase to 13 million by the year 2050. The typical clinical presentation is progressive loss of memory and cognitive function, ultimately leading to a loss of independence and causing a heavy personal toll on the patient and the family. The costs of care of patients with Alzheimer's disease in 2010 were estimated at more than $172 billion in the United States, an annual cost that is predicted to increase to a trillion dollars . . .

• Publisher: Massachusetts Medical Society
• Subject: Adult and adolescent clinical studies / Age / Age of Onset / Aging / Alzheimer Disease - genetics / Alzheimer Disease - metabolism / Alzheimer Disease - psychology / Alzheimer's disease / Amyloid beta-Peptides - metabolism / Atrophy / Biochemical markers / Biological and medical sciences / Biomarkers / Biomarkers - metabolism / Brain - metabolism / Brain - pathology / Cerebrospinal fluid / Cerebrospinal Fluid - metabolism / Cognitive ability / Cross-Sectional Studies / Data processing / Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases / Dementia / Dementia disorders / Family medical history / Female / General aspects / Genes, Dominant / Genetics / Glucose - metabolism / Humans / Longitudinal Studies / Magnetic Resonance Imaging / Male / Medical sciences / Memory / Middle Aged / Mutation / Neurodegenerative diseases / Neuroimaging / Neurology / Neuropsychological Tests / Older people / Organic mental disorders. Neuropsychology / Positron emission tomography / Psychology. Psychoanalysis. Psychiatry / Psychopathology. Psychiatry / Tau protein