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A bacteriocin expression platform for targeting pathogenic bacterial species
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A bacteriocin expression platform for targeting pathogenic bacterial species
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Journal Article
A bacteriocin expression platform for targeting pathogenic bacterial species
2024
Overview
Bacteriocins are antimicrobial peptides that are naturally produced by many bacteria. They hold great potential in the fight against antibiotic resistant bacteria, including ESKAPE pathogens. Engineered live biotherapeutic products (eLBPs) that secrete bacteriocins can be created to deliver targeted bacteriocin production. Here we develop a modular bacteriocin secretion platform that can be used to express and secrete multiple bacteriocins from non-pathogenic
Escherichia coli
host strains. As a proof of concept we create Enterocin A (EntA) and Enterocin B (EntB) secreting strains that show strong antimicrobial activity against
Enterococcus faecalis
and
Enterococcus faecium
in vitro, and characterise this activity in both solid culture and liquid co-culture. We then develop a Lotka-Volterra model that can be used to capture the interactions of these competitor strains. We show that simultaneous exposure to EntA and EntB can delay
Enterococcus
growth. Our system has the potential to be used as an eLBP to secrete additional bacteriocins for the targeted killing of pathogenic bacteria.
Bacteriocins are antimicrobial peptides that are naturally produced by many bacteria. In this work, authors develop a bacteriocin secretion platform, and test, in a proof-of-concept study, antimicrobial efficacy against
Enterococcus faecalis and Enterococcus faecium
.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Anti-Bacterial Agents - pharmacology
/ Bacteria
/ E coli
/ Enterococcus faecalis - drug effects
/ Enterococcus faecalis - genetics
/ Enterococcus faecalis - metabolism
/ Enterococcus faecium - drug effects
/ Enterococcus faecium - genetics
/ Enterococcus faecium - metabolism
/ Escherichia coli - drug effects
/ Escherichia coli - metabolism
/ Humanities and Social Sciences
/ Peptides
/ Science
