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Mosquitocidal toxin-like islands in Bacillus thuringiensis S2160-1 revealed by complete-genome sequence and MS proteomic analysis
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Mosquitocidal toxin-like islands in Bacillus thuringiensis S2160-1 revealed by complete-genome sequence and MS proteomic analysis
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Journal Article
Mosquitocidal toxin-like islands in Bacillus thuringiensis S2160-1 revealed by complete-genome sequence and MS proteomic analysis
2024
Overview
Here, we present the whole genome sequence of Bt S2160-1, a potential alternative to the mosquitocidal model strain,
Bti
. One chromosome genome and four mega-plasmids were contained in Bt S2160-1, and 13 predicted genes encoding predicted insecticidal crystal proteins were identified clustered on one plasmid pS2160-1p2 containing two pathogenic islands (PAIs) designed as PAI-1 (Cry54Ba, Cry30Ea4, Cry69Aa-like, Cry50Ba2-like, Cry4Ca1-like, Cry30Ga2, Cry71Aa-like, Cry72Aa-like, Cry70Aa-like, Cyt1Da2-like and Vpb4C1-like) and PAI-2 (Cyt1Aa-like, and Tpp80Aa1-like). The clusters appear to represent mosquitocidal toxin islands similar to pathogenicity islands. Transcription/translation of 10 of the 13 predicted genes was confirmed by whole-proteome analysis using LTQ-Orbitrap LC–MS/MS. In summary, the present study identified the existence of a mosquitocidal toxin island in
Bacillus thuringiensis
, and provides important genomic information for understanding the insecticidal mechanism of
B. thuringiensis
.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/326
/ Animals
/ Bacillus thuringiensis - genetics
/ Bacillus thuringiensis - metabolism
/ Bacillus thuringiensis Toxins
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Cloning
/ Genomes
/ Hemolysin Proteins - genetics
/ Humanities and Social Sciences
/ Islands
/ Mosquitocidal toxin-like island
/ Plasmids
/ Proteins
/ Proteome
/ Science
/ Toxicity
/ Toxins
