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Screening of immunogenic proteins and evaluation of vaccine candidates against Mycoplasma synoviae
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Screening of immunogenic proteins and evaluation of vaccine candidates against Mycoplasma synoviae
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Journal Article
Screening of immunogenic proteins and evaluation of vaccine candidates against Mycoplasma synoviae
2023
Overview
Mycoplasma synoviae
(
M. synoviae
) is a serious avian pathogen that causes significant economic losses to chicken and turkey producers worldwide. The currently available live attenuated and inactivated vaccines provide limited protection. The objective of this study was to identify potential subunit vaccine candidates using immunoproteomics and reverse vaccinology analyses and to evaluate their preliminary protection. Twenty-four candidate antigens were identified, and five of them, namely RS01790 (a putative sugar ABC transporter lipoprotein), BMP (a substrate-binding protein of the BMP family ABC transporter), GrpE (a nucleotide exchange factor), RS00900 (a putative nuclease), and RS00275 (an uncharacterized protein), were selected to evaluate their immunogenicity and preliminary protection. The results showed that all five antigens had good immunogenicity, and they were localized on the
M. synoviae
cell membrane. The antigens induced specific humoral and cellular immune responses, and the vaccinated chickens exhibited significantly greater body weight gain and lower air sac lesion scores and tracheal mucosal thicknesses. Additionally, the vaccinated chickens had lower
M. synoviae
loads in throat swabs than non-vaccinated chickens. The protective effect of the RS01790, BMP, GrpE, and RS00900 vaccines was better than that of the RS00275 vaccine. In conclusion, our study demonstrates the potential of subunit vaccines as a new approach to developing
M. synoviae
vaccines, providing new ideas for controlling the spread of
M. synoviae
worldwide.
