Asset Details
Do you wish to reserve the book?
Genetic analysis of the X chromosome in people with Lewy body dementia nominates new risk loci
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Genetic analysis of the X chromosome in people with Lewy body dementia nominates new risk loci
Do you wish to request the book?
Genetic analysis of the X chromosome in people with Lewy body dementia nominates new risk loci
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Genetic analysis of the X chromosome in people with Lewy body dementia nominates new risk loci
2024
Overview
Sex influences the prevalence and symptoms of Lewy body dementia (LBD). However, genome-wide association studies typically focus on autosomal variants and exclude sex-specific risk factors. We addressed this gap by performing an X chromosome-wide association study using whole-genome sequence data from 2591 LBD cases and 4391 controls. We identified a significant risk locus within intron 1 of
MAP3K15
(rs141773145, odds ratio = 2.42, 95% confidence interval = 1.65–3.56,
p
-value = 7.0 × 10
−6
) in female LBD cases conditioned for
APOE ε4
dosage. The locus includes an enhancer region that regulates
MAP3K15
expression in ganglionic eminence cells derived from primary cultured neurospheres. Rare variant burden testing showed differential enrichment of missense mutations in
TEX13A
in female LBD cases, that did not reach significance (
p
-value = 1.34 × 10
−4
). These findings support the sex-specific effects of genetic factors and a potential role of Alzheimer’s-related risk for females with LBD.
