Journal Article

Effects of Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3 supplementation on weight loss and gut microbiota of overweight dogs

Cho, Eunbee, Son, Dooheon, Lim, Sanghyun, An, Subin, Lee, Hae-Jeung, Choi, Jihee

2024

Overview

The prevalence of obesity in dogs is increasing worldwide. This study evaluated the effects of a mixed probiotic formula on the weight, body condition score (BCS), blood metabolite profiles, and gut microbiota of overweight and obese dogs over a 12-week supplementation period to determine the anti-obesity effects of Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3. This was a community-based, randomized study that sampled 41 overweight and obese dogs with a veterinarian-determined BCS of 6 or more. The physical activity of all the subjects was measured using a pedometer designed exclusively for dogs. The food intake was measured using the developed application. Only the treatment group received the mixed probiotic formula twice daily (3 g per dose). A significant decrease in body weight ( p  < 0.0001), BCS ( p  < 0.0001), serum TG ( p  < 0.0001), serum TC ( p  = 0.0400), and serum leptin ( p  = 0.0252), and a significantly increased serum adiponectin levels ( p  = 0.0007) were observed in the treatment group compared with the values in the control group. Microbiota analysis showed that Lactiplantibacillus increased and Erysipelatoclostridium , Staphylococcus , and Gemella decreased more significantly in the treatment group than in the control group. These results suggested that Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3 may be effective in alleviating obesity in dogs.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 631/601 / 692/699 / Adiponectin / Animals / Bifidobacterium breve / Bifidobacterium breve CBT BR3 / Body weight / Body weight loss / Dietary Supplements / Dog / Dog Diseases - microbiology / Dog Diseases - therapy / Dogs / Female / Food intake / Gastrointestinal Microbiome - drug effects / Gut microbiota / Humanities and Social Sciences / Intestinal microflora / Lactiplantibacillus plantarum / Lactiplantibacillus plantarum CBT LP3 / Lactobacillus plantarum / Leptin / Male / Metabolites / Microbiota / multidisciplinary / Obesity / Obesity - microbiology / Obesity - therapy / Overweight / Overweight - microbiology / Overweight - therapy / Physical activity / Probiotics / Probiotics - administration & dosage / Probiotics - pharmacology / Science / Science (multidisciplinary) / Veterinary medicine / Weight / Weight control / Weight Loss - drug effects