Journal Article

Electrical lymph node scanning (ELS) system for real-time intra-operative detection of involved axillary lymph nodes in adjuvant breast cancer patients

Khoundabi, Batoul, Akbari, Mohammad Esmaeil, Shojaeian, Fatemeh, Hoseinpour, Parisa, Abbasvandi, Fereshteh, Yousefpour, Narges, Moradi, Afshin, Sami, Nafiseh, Mahdavi, Reihane, Ataee, Hossein, Abdolahad, Mohammad, Akbari, Atieh, Aghaei, Faeze, Bayat, Mahdis, Jahanbakhshi, Fahimeh, Omrani Hashemi, Maryam, Mousavi Kiasary, Seyed Mohamad Sadegh, Bagherhosseini, Najmeh, Hajighasemi, Farzane

2024

Overview

Lymph node (LN) status is an essential prognostic factor in breast cancer (BC) patients, with an important role in the surgical and therapeutic plan. Recently, we have been developed a novel system for real-time intra-operative electrical LN scanning in BC patients. The ELS scores were calibrated by pathological evaluation of the LNs. Herein, we evaluated the efficacy of ELS in a prospective study for non-chemo-treated breast cancer patients. This is a prospective study in which ELS scores are blind for pathologists who declare the clearance or involvement of LNs based on permanent pathology as the gold standard. ELS and frozen-section (FS) pathology results were achieved intra-operatively, and samples were sent for the permanent pathology. The score of ELS did not affect the surgeons’ decision, and the treatment approach was carried out based on FS pathology and pre-surgical data, such as imaging and probable biopsies. Patients were recruited from October 2021 through November 2022, and 381 lymph nodes of 97 patients were included in the study. In this study we recruited 38 patients (39.2%) with sentinel lymph node biopsy (SLNB) and 59 patients (60.8%) with ALND. Of the 381 LNs scored by ELS, 329 sentinel LNs underwent routine pathology, while others (n = 52) underwent both FS and permanent pathology. ELS showed a sensitivity of 91.4% for node-positive patients, decreasing to 84.8% when considering all LNs. Using ROC analysis, ELS diagnosis showed a significant AUC of 0.878 in relation to the permanent pathology gold standard. Comparison of ELS diagnosis for different tumor types and LN sizes demonstrated no significant differences, while increasing LN size correlated with enhanced ELS sensitivity. This study confirmed ELS’s efficacy in real-time lymph node detection among non-chemo-treated breast cancer patients. The use of ELS’s pathological scoring for intra-operative LN diagnosis, especially in the absence of FS pathology or for non-sentinel LN involvement, could improve prognosis and reduce complications by minimizing unnecessary dissection.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 631/67 / 639/166 / Adult / Aged / Axilla / Biopsy / Breast cancer / Breast cancer surgery / Breast Neoplasms - pathology / Breast Neoplasms - surgery / Diagnosis / Electrical impedance spectroscopy (EIS) / Female / Humanities and Social Sciences / Humans / Impedance phase slope (IPS) / Lymph Node Excision - methods / Lymph nodes / Lymph Nodes - pathology / Lymphatic Metastasis / Lymphatic system / Middle Aged / multidisciplinary / Nodal staging / Pathology / Prospective Studies / Scanning / Science / Science (multidisciplinary) / Sentinel Lymph Node Biopsy - methods