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Molecular signatures of cortical expansion in the human foetal brain
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Molecular signatures of cortical expansion in the human foetal brain
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Journal Article
Molecular signatures of cortical expansion in the human foetal brain
2024
Overview
The third trimester of human gestation is characterised by rapid increases in brain volume and cortical surface area. Recent studies have revealed a remarkable molecular diversity across the prenatal cortex but little is known about how this diversity translates into the differential rates of cortical expansion observed during gestation. We present a digital resource, μBrain, to facilitate knowledge translation between molecular and anatomical descriptions of the prenatal brain. Using μBrain, we evaluate the molecular signatures of preferentially-expanded cortical regions, quantified in utero using magnetic resonance imaging. Our findings demonstrate a spatial coupling between areal differences in the timing of neurogenesis and rates of neocortical expansion during gestation. We identify genes, upregulated from mid-gestation, that are highly expressed in rapidly expanding neocortex and implicated in genetic disorders with cognitive sequelae. The μBrain atlas provides a tool to comprehensively map early brain development across domains, model systems and resolution scales.
The third trimester of human gestation is characterised by rapid increases in cortical surface area. Here, authors show that increased rates of cortical expansion are associated with differences in the timing of neurogenesis.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 49/61
/ 59/57
/ Brain
/ Brain - growth & development
/ Cerebral Cortex - diagnostic imaging
/ Cerebral Cortex - embryology
/ Cerebral Cortex - growth & development
/ Cerebral Cortex - metabolism
/ Female
/ Gene Expression Regulation, Developmental
/ Humanities and Social Sciences
/ Humans
/ Neocortex - diagnostic imaging
/ Neocortex - growth & development
/ Neurodevelopmental disorders
/ Science
