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A non-canonical striatopallidal Go pathway that supports motor control
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A non-canonical striatopallidal Go pathway that supports motor control
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Journal Article
A non-canonical striatopallidal Go pathway that supports motor control
2023
Overview
In the classical model of the basal ganglia, direct pathway striatal projection neurons (dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to regulate motor function. Recent studies have re-established that dSPNs also possess axon collaterals within the globus pallidus (GPe) (bridging collaterals), yet the significance of these collaterals for behavior is unknown. Here we use in vivo optical and chemogenetic tools combined with deep learning approaches in mice to dissect the roles of dSPN GPe collaterals in motor function. We find that dSPNs projecting to the SNr send synchronous motor-related information to the GPe via axon collaterals. Inhibition of native activity in dSPN GPe terminals impairs motor activity and function via regulation of Npas1 neurons. We propose a model by which dSPN GPe axon collaterals (striatopallidal Go pathway) act in concert with the canonical terminals in the SNr to support motor control by inhibiting Npas1 neurons.
The basal ganglia direct and indirect pathways are classically described as anatomically segregated and functionally opposing. Here the authors describe a non-canonical direct pathway made of axon collaterals to the globus pallidus that promotes motor action.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/51
/ 14/19
/ 14/35
/ 14/63
/ 64/110
/ 9/10
/ Animals
/ Basic Helix-Loop-Helix Transcription Factors - genetics
/ Basic Helix-Loop-Helix Transcription Factors - metabolism
/ Behavior
/ Corpus Striatum - metabolism
/ Dopamine
/ Ganglia
/ Globus Pallidus - physiology
/ Humanities and Social Sciences
/ Mice
/ Nerve Tissue Proteins - genetics
/ Nerve Tissue Proteins - metabolism
/ Neurons
/ Science
/ Surgeons
