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Acute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain
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Acute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain
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Journal Article
Acute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain
2012
Overview
The zebrafish regenerates its brain after injury and hence is a useful model organism to study the mechanisms enabling regenerative neurogenesis, which is poorly manifested in mammals. Yet the signaling mechanisms initiating such a regenerative response in fish are unknown. Using cerebroventricular microinjection of immunogenic particles and immunosuppression assays, we showed that inflammation is required and sufficient for enhancing the proliferation of neural progenitors and subsequent neurogenesis by activating injury-induced molecular programs that can be observed after traumatic brain injury. We also identified cysteinyl leukotriene signaling as an essential component of inflammation in the regenerative process of the adult zebrafish brain. Thus, our results demonstrate that in zebrafish, in contrast to mammals, inflammation is a positive regulator of neuronal regeneration in the central nervous system.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Adult and adolescent clinical studies
/ Adults
/ Anatomy
/ Animals
/ Biological and medical sciences
/ Brain
/ Brain Injuries - physiopathology
/ Cellular
/ Damage
/ Encephalitis - physiopathology
/ Fish
/ Human
/ humans
/ Injuries
/ Injuries of the nervous system and the skull. Diseases due to physical agents
/ Lesions
/ Mammals
/ Neural Stem Cells - physiology
/ Neurons
/ Organic mental disorders. Neuropsychology
/ Psychology. Psychoanalysis. Psychiatry
/ Receptors, Leukotriene - metabolism
/ Stella
