Journal Article

Beneficial Effect of TaON-Ag Nanocomposite Titanium on Antibacterial Capacity in Orthopedic Application

Hu, Chih-Chien, Chang, Yuhan, Ueng, Steve Wen-Neng, Chang, Chih-Hsiang, Hsieh, Jang-Hsing

2020

Overview

In this study, a novel oxygenated nanocomposite thin film, TaON-Ag, was investigated in vitro and in vivo to evaluate its biocompatibility and antibacterial ability. The antibacterial ability of TaON-Ag nanocomposite-coated titanium (Ti) was evaluated using the Kirby-Bauer disk diffusion susceptibility test. The effects of TaON-Ag nanocomposite-coated metal on osteogenesis were further evaluated in an in vitro osteogenic culture model with rat marrow-derived mesenchymal stem cells (rMSCs). Furthermore, titanium rods coated with TaON-Ag were implanted into a rat femur fracture model either with or without osteomyelitis to investigate the effects of TaON-Ag in osteogenesis. The TaON-Ag-coated Ti exhibited an effective antibacterial effect against , coagulase-negative , and the Gram-negative strains and . Using an osteogenic culture with rMSCs and a rat femoral fracture model, the TaON-Ag-coated Ti did not interfere with the ossification of rMSCs in vitro or during fracture healing in vivo. Field-emission scanning electron microscopy (FE-SEM) revealed that coating with TaON-Ag could inhibit pathogen adhesion and biofilm formation in both and Using the proposed novel oxygenation process, TaON-Ag nanocomposite-coated Ti yielded robust biocompatibility and antibacterial ability against common microorganisms in orthopedic infections, thereby demonstrating potential for use in clinical applications.

• Publisher: Dove Medical Press Limited,Taylor & Francis Ltd,Dove,Dove Medical Press
• Subject: Animals / Anti-Bacterial Agents - chemistry / Anti-Bacterial Agents - pharmacology / antibacterial ability / Antimicrobial agents / Bacteria / Biocompatibility / biofilm / Biofilms / Biological activity / E coli / Escherichia coli / Femoral Neck Fractures - microbiology / Fractures / Internal fixation / Materials Testing / Medical equipment / Metals / Methicillin / Nanocomposites / Nanocomposites - chemistry / Nitrogen / Original Research / Orthopedics / ossification / Osteogenesis - drug effects / Osteomyelitis - prevention & control / Plasma / Prostheses / Prostheses and Implants / Rats / Silver / Silver - chemistry / silver nanoparticles / Staphylococcus infections / Stem cells / Thin films / Titanium / Titanium - chemistry / Titanium - pharmacology / Transplants & implants