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Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss

by Brock, Penelope R , Childs, Margaret , Rechnitzer, Catherine , Covezzoli, Anna , Sullivan, Michael J , Morland, Bruce , Brichard, Bénédicte , Dall’Igna, Patrizia , Hiyama, Eiso , Skeen, Jane , Brugières, Laurence , Perilongo, Giorgio , Laithier, Véronique , Veal, Gareth J , Rajput, Kaukab , Ronghe, Milind , Ansari, Marc , Mateos, M. Elena , Rangaswami, Arun A , Neuwelt, Edward A , Czauderna, Piotr , Capra, Michael , Roebuck, Derek , Maibach, Rudolf

in Adolescent / Cancer / Cancer therapies / Chemotherapy / Child / Child, Preschool / Children / Children & youth / Cisplatin / Cisplatin - administration & dosage / Cisplatin - adverse effects / Deoxyribonucleic acid / Design / DNA / Doxorubicin - administration & dosage / Drug Therapy, Combination / Female / Follow-Up Studies / Glomerular Filtration Rate / Hearing loss / Hearing Loss - chemically induced / Hearing Loss - prevention & control / Hepatoblastoma - drug therapy / Hepatoblastoma - mortality / Humans / Incidence / Infant / Liver diseases / Liver Neoplasms - drug therapy / Liver Neoplasms - mortality / Male / Medical imaging / Medical research / Metastases / Ototoxicity / Single-Blind Method / Sodium / Sodium thiosulfate / Surgery / Survival / Survival Analysis / Thiosulfate / Thiosulfates - administration & dosage / Thiosulfates - adverse effects / Thiosulfates - therapeutic use / α-Fetoprotein

2018

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Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss

2018

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2018

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Journal Article

Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss

Brock, Penelope R,

Childs, Margaret,

Rechnitzer, Catherine,

Covezzoli, Anna,

Sullivan, Michael J,

Morland, Bruce,

Brichard, Bénédicte,

Dall’Igna, Patrizia,

Hiyama, Eiso,

Skeen, Jane,

Brugières, Laurence,

Perilongo, Giorgio,

Laithier, Véronique,

Veal, Gareth J,

Rajput, Kaukab,

Ronghe, Milind,

Ansari, Marc,

Mateos, M. Elena,

Rangaswami, Arun A,

Neuwelt, Edward A,

Czauderna, Piotr,

Capra, Michael,

Roebuck, Derek,

Maibach, Rudolf

2018

Overview

Cisplatin is an effective treatment for hepatoblastoma but often leads to lifelong irreversible hearing loss. The addition of sodium thiosulfate 6 hours after cisplatin administration preserved the antitumor effect and led to a lower risk of hearing loss (33% vs. 63%).

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Publisher

Massachusetts Medical Society

Subject

/ Cancer

/ Child