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Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease
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Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease
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Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease
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Journal Article
Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease
2023
Overview
Microglia play a critical role in brain homeostasis and disease progression. In neurodegenerative conditions, microglia acquire the neurodegenerative phenotype (MGnD), whose function is poorly understood. MicroRNA-155 (miR-155), enriched in immune cells, critically regulates MGnD. However, its role in Alzheimer’s disease (AD) pathogenesis remains unclear. Here, we report that microglial deletion of miR-155 induces a pre-MGnD activation state via interferon-γ (IFN-γ) signaling, and blocking IFN-γ signaling attenuates MGnD induction and microglial phagocytosis. Single-cell RNA-sequencing analysis of microglia from an AD mouse model identifies Stat1 and Clec2d as pre-MGnD markers. This phenotypic transition enhances amyloid plaque compaction, reduces dystrophic neurites, attenuates plaque-associated synaptic degradation and improves cognition. Our study demonstrates a miR-155-mediated regulatory mechanism of MGnD and the beneficial role of IFN-γ-responsive pre-MGnD in restricting neurodegenerative pathology and preserving cognitive function in an AD mouse model, highlighting miR-155 and IFN-γ as potential therapeutic targets for AD.
Publisher
Nature Publishing Group,CCSD,Nature Publishing Group US
Subject
/ 13/2
/ 13/31
/ 13/51
/ 14/1
/ 14/19
/ 38/39
/ 45/77
/ 45/90
/ 45/91
/ 64/60
/ 82/58
/ Alzheimer Disease - metabolism
/ Amyloid
/ Amyloid beta-Peptides - metabolism
/ Animal Genetics and Genomics
/ Animals
/ Axons
/ Biomedical and Life Sciences
/ Interferon-gamma - metabolism
/ Mice
/ miRNA
/ Plaque, Amyloid - metabolism
/ Regulatory mechanisms (biology)
ISBN
0010034884000
