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Different factors control long-term versus short-term outcomes for bacterial colonisation of a urinary catheter
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Different factors control long-term versus short-term outcomes for bacterial colonisation of a urinary catheter
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Journal Article
Different factors control long-term versus short-term outcomes for bacterial colonisation of a urinary catheter
2025
Overview
Urinary catheters are used extensively in hospitals and long-term care and they are highly prone to infection. Understanding the pathways by which bacteria colonise a urinary catheter could guide strategies to mitigate infection, but quantitative models for this colonisation process are lacking. Here we present a mathematical model for bacterial colonisation of a urinary catheter that integrates population dynamics and fluid dynamics. The model describes bacteria migrating up the outside surface of the catheter, spreading into the bladder and being swept through the catheter lumen. Computer simulations of the model reveal that clinical outcomes for long-term versus short-term catheterisation are controlled by different factors: the rate of urine production by the kidneys as opposed to urethral length, catheter surface properties and bacterial motility. Our work may help explain variable susceptibility to catheter-associated urinary tract infection (CAUTI) among individuals and the mixed success of antimicrobial surface coatings. Our model suggests that for long-term catheterised patients, increasing fluid intake or reducing residual urine volume in the bladder may help prevent infection, while antimicrobial surface coatings are predicted to be effective only for short-term catheterised patients. Therefore, different catheter management strategies could be rationally targeted to long-term vs short-term catheterised patients.
Bull et al. developed a mathematical model for how bacteria colonise urinary catheters. The model reveals that different strategies may be needed to reduce catheter associated infection for long-term vs short-term catherised patients
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Bacteria
/ Bacteria - growth & development
/ Bladder
/ Catheter-Related Infections - microbiology
/ Catheter-Related Infections - prevention & control
/ Coatings
/ Humanities and Social Sciences
/ Humans
/ Patients
/ Science
/ Urinary Bladder - microbiology
/ Urinary Catheterization - adverse effects
/ Urinary Catheters - adverse effects
/ Urinary Catheters - microbiology
/ Urinary Tract Infections - etiology
/ Urinary Tract Infections - microbiology
/ Urinary Tract Infections - prevention & control
/ Urine
