Asset Details
Do you wish to reserve the book?
Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk
Do you wish to request the book?
Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk
2025
Overview
Bone marrow adipose tissue, as a distinct adipose subtype, has been implicated in the pathophysiology of skeletal, metabolic, and hematopoietic disorders. To identify its underlying genetic factors, we utilized a deep learning algorithm capable of quantifying bone marrow fat fraction (BMFF) in the vertebrae and proximal femur using magnetic resonance imaging data of over 38,000 UK Biobank participants. Genome-wide association analyses uncovered 373 significant BMFF-associated variants (
P
-value < 5 × 10
−9
), with enrichment in bone remodeling, metabolism, and hematopoiesis pathway. Furthermore, genetic correlation highlighted a significant association between BMFF and skeletal disease. In about 300,000 individuals, polygenic risk scores derived from three proximal femur BMFF were significantly associated with increased osteoporosis risk. Notably, Mendelian randomization analyses revealed a causal link between proximal femur BMFF and osteoporosis. Here, we show critical insights into the genetic determinants of BMFF and offer perspectives on the biological mechanisms driving osteoporosis development.
Bone marrow adipose tissue is linked to skeletal and metabolic health. Here, the authors use deep learning and GWAS to identify genetic determinants of bone marrow fat and reveal a causal link between femoral fat content and osteoporosis risk.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 59/57
/ 692/499
/ Adipose Tissue - diagnostic imaging
/ Aged
/ Body fat
/ Bone Marrow - diagnostic imaging
/ Female
/ Femur
/ Genes
/ Genetic Predisposition to Disease
/ Genome-Wide Association Study
/ Genomes
/ Humanities and Social Sciences
/ Humans
/ Male
/ Mendelian Randomization Analysis
/ Osteoporosis - diagnostic imaging
/ Polymorphism, Single Nucleotide
/ Risk
/ Science
