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Anti-Müllerian hormone signalling sustains circadian homeostasis in zebrafish
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Anti-Müllerian hormone signalling sustains circadian homeostasis in zebrafish
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Journal Article
Anti-Müllerian hormone signalling sustains circadian homeostasis in zebrafish
2025
Overview
Circadian clocks temporally orchestrate the behavioural and physiological rhythms. The core molecules establishing the circadian clock are clear; however, the critical signalling pathways that cause or favour the homeostasis are poorly understood. Here, we report that anti-Müllerian hormone (Amh)-mediated signalling plays an important role in sustaining circadian homeostasis in zebrafish. Notably,
amh
knockout dampens molecular clock oscillations and disrupts both behavioural and hormonal circadian rhythms, which are recapitulated in
bmpr2a
null mutants. Somatotropes and gonadotropes are identified as Amh-targeted pituitary cell populations. Single-cell transcriptome analysis further reveals a lineage-specific regulation of pituitary clock by Amh. Moreover, Amh-induced effect on clock gene expression can be abolished by blocking Smad1/5/9 phosphorylation and
bmpr2a
knockout. Mechanistically, Amh binds to its receptors, Bmpr2a/Bmpr1bb, which in turn activate Smad1/5/9 by phosphorylation and promote circadian gene expression. Our findings reveal a key hormone signalling pathway for circadian homeostasis in zebrafish with implications for rhythmic organ functions and circadian health.
The mechanisms underlying circadian homeostasis remain elusive. Here, the authors show that anti-Müllerian hormone (Amh)-mediated signaling sustains molecular clock oscillations in the pituitary gland, thereby maintaining circadian homeostasis at both tissue and systemic levels.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/1
/ 14
/ 14/19
/ 38
/ 38/32
/ 49
/ 49/91
/ 631/136
/ 82/103
/ Animals
/ Anti-Mullerian Hormone - genetics
/ Anti-Mullerian Hormone - metabolism
/ Bone Morphogenetic Protein Receptors, Type II - genetics
/ Bone Morphogenetic Protein Receptors, Type II - metabolism
/ Circadian Clocks - physiology
/ Circadian Rhythm - physiology
/ Humanities and Social Sciences
/ Pituitary Gland - metabolism
/ Receptors, Peptide - metabolism
/ Science
