Asset Details
Do you wish to reserve the book?
In-vivo assessment of vascular endothelial injury in a rat model of unilateral carotid artery injury using 4D-flow MRI
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
In-vivo assessment of vascular endothelial injury in a rat model of unilateral carotid artery injury using 4D-flow MRI
Do you wish to request the book?
In-vivo assessment of vascular endothelial injury in a rat model of unilateral carotid artery injury using 4D-flow MRI
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
In-vivo assessment of vascular endothelial injury in a rat model of unilateral carotid artery injury using 4D-flow MRI
2025
Overview
Herein, 4D-flow MRI was performed on the bilateral carotid arteries in a rat model of unilateral carotid artery injury to analyze changes in flow velocity, flow rate, wall shear stress (WSS), and cross-sectional area due to endothelial injury. MR images of the rat carotid artery were acquired using 7T-MRI. Seven control rats and 16 rats with right endothelial injury (VED) were used. For five of the VED models where blood flow in both the right and left common carotid arteries was confirmed, 4D-flow MRI was performed after obtaining 3D images using the time of flight method. MRI was performed to calculate the flow velocity, flow rate, WSS, and cross-sectional area of the proximal, middle, and distal carotid arteries. In all five VED models, blood flow rate and WSS were predominantly decreased at the proximal injured side compared to the ipsilateral control side (
p
< 0.05). The cross-sectional area of the vessel distal to the injured side of the VED model was reduced compared to that of the non-injured side (
p
< 0.05). A comparison of the proximal part of the uninjured side between the control group and VED model showed that the vascular cross-sectional area was predominantly increased in the VED model (
p
< 0.05). 4D-flow MRI with 7T-MRI enabled analysis of changes in flow velocity, flow rate, WSS, and cross-sectional area due to vascular endothelial injury.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Animals
/ Carotid Arteries - diagnostic imaging
/ Carotid Arteries - physiopathology
/ Carotid Artery Injuries - diagnostic imaging
/ Carotid Artery Injuries - pathology
/ Carotid Artery Injuries - physiopathology
/ Endothelium, Vascular - diagnostic imaging
/ Endothelium, Vascular - injuries
/ Endothelium, Vascular - pathology
/ Endothelium, Vascular - physiopathology
/ Humanities and Social Sciences
/ Magnetic Resonance Imaging - methods
/ Male
/ Rats
/ Science
/ Velocity
